Calcified Pleural Dissemination and Malignant Pleural Effusion in Dedifferentiated Chondrosarcoma: A Case Report with an Institutional Review
Abstract
Dedifferentiated chondrosarcoma (DDCS) rarely presents with pleural dissemination or malignant pleural effusion. A 62-year-old man developed massive left pleural effusion with diffuse calcified pleural thickening and nodular lesions. Pleural fluid cell block immunohistochemistry showed cytokeratin AE1/AE3 negativity and SATB2 positivity, suggesting a mesenchymal tumor. Pelvic imaging suggested a chondroid matrix, while a biopsy revealed a high-grade osteoid-producing component with an IDH1 p.R132C mutation. Integrated pleural fluid, imaging, histopathological, and molecular findings supported the diagnosis of DDCS. An institutional review provided descriptive context but could not estimate the DDCS-specific frequency. This case highlights an uncommon pleural presentation and the adjunctive value of a pleural fluid cell block analysis.
Related
- Single-cell analysis reveals the potential immunoregulatory role of C3 + malignant cell subpopulations in dedifferentiated liposarcoma.
- Mandibular Chondrosarcoma Mimicking an Odontogenic Infection: A Case Report
- Postdiagnostic pretreatment risk stratification for chondrosarcoma survival using routinely available registry variables: a SEER-based temporal validation study
- Case Report: Recurrent retroperitoneal dedifferentiated liposarcoma after surgery
- Two-stage surgical resection of a massive primary posterior mediastinal dedifferentiated liposarcoma with bilateral thoracic extension: a case report
BibTeX
@article{ichikawa2026calcified,
title = {{Calcified Pleural Dissemination and Malignant Pleural Effusion in Dedifferentiated Chondrosarcoma: A Case Report with an Institutional Review}},
author = {Takeru Ichikawa and Miho Fujiwara and Hiromi Watanabe and Akiko Sato and Tetsuya Isoda and Yoshiyuki Ayada and Takahiro Kitayama and Yosuke Togashi and Yoshinobu Maeda and Go Makimoto},
journal = {Internal Medicine},
year = {2026},
month = oct,
doi = {10.2169/internalmedicine.8150-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8150-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Calcified Pleural Dissemination and Malignant Pleural Effusion in Dedifferentiated Chondrosarcoma: A Case Report with an Institutional Review
AU - Takeru Ichikawa
AU - Miho Fujiwara
AU - Hiromi Watanabe
AU - Akiko Sato
AU - Tetsuya Isoda
AU - Yoshiyuki Ayada
AU - Takahiro Kitayama
AU - Yosuke Togashi
AU - Yoshinobu Maeda
AU - Go Makimoto
PY - 2026
DA - 2026/10/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.8150-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8150-26/_article
AB - Dedifferentiated chondrosarcoma (DDCS) rarely presents with pleural dissemination or malignant pleural effusion. A 62-year-old man developed massive left pleural effusion with diffuse calcified pleural thickening and nodular lesions. Pleural fluid cell block immunohistochemistry showed cytokeratin AE1/AE3 negativity and SATB2 positivity, suggesting a mesenchymal tumor. Pelvic imaging suggested a chondroid matrix, while a biopsy revealed a high-grade osteoid-producing component with an IDH1 p.R132C mutation. Integrated pleural fluid, imaging, histopathological, and molecular findings supported the diagnosis of DDCS. An institutional review provided descriptive context but could not estimate the DDCS-specific frequency. This case highlights an uncommon pleural presentation and the adjunctive value of a pleural fluid cell block analysis.
SN - 1349-7235
SN - 0918-2918
ER -