Coexisting Hyperuricemia and High Urinary Uric Acid Excretion Are Associated With a Higher Prevalence of Obesity and Metabolic Syndrome in Type 2 Diabetes
- 1Department of Endocrinology and Metabolism Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Key Clinical Center for Metabolic Disease Shanghai China sjtu.edu.cn
- 2Department of Endocrinology The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian China fjmu.edu.cn
- 3Health Management Center National Clinical Research Center for Metabolic Diseases Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease Hunan Provincial Key Laboratory of Metabolic Bone Diseases Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University Changsha Hunan China csu.edu.cn
Abstract
Purpose: Both hyperuricemia and high urinary uric acid excretion (UUAE) are strongly associated with obesity and metabolic syndrome (MetS). However, few studies have examined the joint association of these two conditions with obesity and MetS. This study was aimed at investigating whether the concomitant presence of high serum uric acid (SUA) and high UUAE was associated with higher odds of obesity and MetS in patients with Type 2 diabetes mellitus (T2DM).
Methods: This cross‐sectional study included 7051 Chinese patients with T2DM in a real‐world setting. Participants were divided into four groups, including patients with normal SUA and UUAE (Group 1), normal SUA and high UUAE (Group 2), high SUA and normal UUAE (Group 3), and high SUA and UUAE (Group 4). The clinical characteristics and prevalence of obesity and MetS were compared among these groups.
Results: After adjustment, compared with Group 1, both Groups 2 and 3 had a significantly elevated prevalence of obesity (42.6%, 63.2%, and 62.6%, respectively, p < 0.001 for trend), abdominal obesity (62.4%, 76.5%, and 81.3%, respectively, p < 0.001 for trend), and MetS (66.4%, 78.3%, and 87.8%, respectively, p < 0.001 for trend). Moreover, the prevalence of obesity, abdominal obesity, and MetS further increased in Group 4 (84.6% for obesity, 93.6% for abdominal obesity, and 88.5% for MetS). Additionally, serum CRP levels and HOMA2‐IR values were significantly higher in the other three groups than in Group 1, with the highest values in Group 4 (p < 0.001 for trend).
Conclusion: The concomitant presence of elevated SUA and UUAE was associated with higher odds of both obesity and MetS among patients with T2DM. Thus, the combined consideration of SUA and UUAE levels may help to identify those T2DM patients with a greater burden of obesity and MetS.
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BibTeX
@article{xu2026coexisting,
title = {{Coexisting Hyperuricemia and High Urinary Uric Acid Excretion Are Associated With a Higher Prevalence of Obesity and Metabolic Syndrome in Type 2 Diabetes}},
author = {Man-Rong Xu and Meng-Han Li and Cui-Chun Zhao and Yu-Jie Wang and Ming-Yun Chen and Ya-Wen Zhang and Jun-Xi Lu and Chun Yue and Lu-Lu Xu and Zhi-Feng Sheng and Lian-Xi Li},
journal = {Journal of Diabetes Research},
year = {2026},
month = oct,
doi = {10.1155/jdr/8461568},
url = {https://doi.org/10.1155/jdr/8461568},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Coexisting Hyperuricemia and High Urinary Uric Acid Excretion Are Associated With a Higher Prevalence of Obesity and Metabolic Syndrome in Type 2 Diabetes
AU - Man-Rong Xu
AU - Meng-Han Li
AU - Cui-Chun Zhao
AU - Yu-Jie Wang
AU - Ming-Yun Chen
AU - Ya-Wen Zhang
AU - Jun-Xi Lu
AU - Chun Yue
AU - Lu-Lu Xu
AU - Zhi-Feng Sheng
AU - Lian-Xi Li
PY - 2026
DA - 2026/10/26
JO - Journal of Diabetes Research
DO - 10.1155/jdr/8461568
UR - https://doi.org/10.1155/jdr/8461568
AB - Purpose: Both hyperuricemia and high urinary uric acid excretion (UUAE) are strongly associated with obesity and metabolic syndrome (MetS). However, few studies have examined the joint association of these two conditions with obesity and MetS. This study was aimed at investigating whether the concomitant presence of high serum uric acid (SUA) and high UUAE was associated with higher odds of obesity and MetS in patients with Type 2 diabetes mellitus (T2DM). Methods: This cross‐sectional study included 7051 Chinese patients with T2DM in a real‐world setting. Participants were divided into four groups, including patients with normal SUA and UUAE (Group 1), normal SUA and high UUAE (Group 2), high SUA and normal UUAE (Group 3), and high SUA and UUAE (Group 4). The clinical characteristics and prevalence of obesity and MetS were compared among these groups. Results: After adjustment, compared with Group 1, both Groups 2 and 3 had a significantly elevated prevalence of obesity (42.6%, 63.2%, and 62.6%, respectively, p < 0.001 for trend), abdominal obesity (62.4%, 76.5%, and 81.3%, respectively, p < 0.001 for trend), and MetS (66.4%, 78.3%, and 87.8%, respectively, p < 0.001 for trend). Moreover, the prevalence of obesity, abdominal obesity, and MetS further increased in Group 4 (84.6% for obesity, 93.6% for abdominal obesity, and 88.5% for MetS). Additionally, serum CRP levels and HOMA2‐IR values were significantly higher in the other three groups than in Group 1, with the highest values in Group 4 (p < 0.001 for trend). Conclusion: The concomitant presence of elevated SUA and UUAE was associated with higher odds of both obesity and MetS among patients with T2DM. Thus, the combined consideration of SUA and UUAE levels may help to identify those T2DM patients with a greater burden of obesity and MetS.
SN - 2314-6745
SN - 2314-6753
ER -