Prevalence and factors associated with metabolic syndrome among adults with stage 3–5 chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania
- 1Department of Internal Medicine, School of Medicine and Dentistry, The University of Dodoma
- 2Department of Internal Medicine, The Benjamin Mkapa Hospital
- 3Department of Community Medicine, School of Medicine and Dentistry, The University of Dodoma
Abstract
Metabolic syndrome (MetS) is increasing globally among adults with chronic kidney disease (CKD), and accelerates CKD progression, cardiovascular complications, poor quality of life, increased healthcare costs, and premature mortality. This study determined the prevalence and associated factors with MetS among adults with CKD attending tertiary hospitals in Dodoma. A hospital-based cross-sectional study was conducted among 350 adults with CKD between November 2024 and May 2025 using consecutive sampling. Data were collected through interviews, clinical assessments, and laboratory investigations following standard procedures. MetS was defined using the Adult Treatment Panel III criteria. Data were analyzed using SPSS version 26; and multivariable logistic regression identified associated factors. The prevalence of MetS was 35.4% (124/350). Most affected patients had hypertension (91%), central obesity (87%), impaired fasting glucose (75%), low HDL (68.5%), and elevated triglycerides (64.5%). Factors independently associated with MetS included CKD duration > 60 months, alcohol consumption, physical inactivity, elevated CRP, age ≥ 60 years, advanced CKD (stage 4 and 5), and elevated serum uric acid. MetS is highly prevalent among adults with CKD in this setting and is strongly associated with advanced age, unhealthy lifestyles, prolonged and advanced CKD, inflammation, and hyperuricemia. Routine screening, lifestyle modification interventions, early risk factor management, and integrated care for CKD patients are recommended to reduce cardiovascular risk and disease progression.
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BibTeX
@article{mselema2026prevalence,
title = {{Prevalence and factors associated with metabolic syndrome among adults with stage 3–5 chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania}},
author = {Joseph Mselema and Alfred Meremo and Francisca Komanya and Emmanuel Sindato and Deogratius Bintabara},
journal = {Scientific Reports},
year = {2026},
month = jul,
doi = {10.1038/s41598-026-63633-6},
url = {https://doi.org/10.1038/s41598-026-63633-6},
note = {CC BY},
}
RIS
TY - JOUR
TI - Prevalence and factors associated with metabolic syndrome among adults with stage 3–5 chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania
AU - Joseph Mselema
AU - Alfred Meremo
AU - Francisca Komanya
AU - Emmanuel Sindato
AU - Deogratius Bintabara
PY - 2026
DA - 2026/07/01
JO - Scientific Reports
DO - 10.1038/s41598-026-63633-6
UR - https://doi.org/10.1038/s41598-026-63633-6
AB - Metabolic syndrome (MetS) is increasing globally among adults with chronic kidney disease (CKD), and accelerates CKD progression, cardiovascular complications, poor quality of life, increased healthcare costs, and premature mortality. This study determined the prevalence and associated factors with MetS among adults with CKD attending tertiary hospitals in Dodoma. A hospital-based cross-sectional study was conducted among 350 adults with CKD between November 2024 and May 2025 using consecutive sampling. Data were collected through interviews, clinical assessments, and laboratory investigations following standard procedures. MetS was defined using the Adult Treatment Panel III criteria. Data were analyzed using SPSS version 26; and multivariable logistic regression identified associated factors. The prevalence of MetS was 35.4% (124/350). Most affected patients had hypertension (91%), central obesity (87%), impaired fasting glucose (75%), low HDL (68.5%), and elevated triglycerides (64.5%). Factors independently associated with MetS included CKD duration > 60 months, alcohol consumption, physical inactivity, elevated CRP, age ≥ 60 years, advanced CKD (stage 4 and 5), and elevated serum uric acid. MetS is highly prevalent among adults with CKD in this setting and is strongly associated with advanced age, unhealthy lifestyles, prolonged and advanced CKD, inflammation, and hyperuricemia. Routine screening, lifestyle modification interventions, early risk factor management, and integrated care for CKD patients are recommended to reduce cardiovascular risk and disease progression.
SN - 2045-2322
ER -