The Canadian Pediatric Imaging Platform (C-PIP) Reference Sample: Neuroimaging Protocol and Cross-site Validation for Harmonized Multimodal Pediatric Imaging
- 1University of Toronto, Toronto, Ontario, Canada
Abstract
Understanding how the human brain matures from infancy through adolescence is essential for identifying factors that influence health outcomes. Magnetic resonance imaging (MRI) provides powerful tools for characterizing structural, microstructural, functional, and metabolic aspects of brain development; however, many pediatric imaging studies are constrained by small sample sizes, limited geographic diversity, lack of longitudinal measurement, restricted age ranges, and heterogeneous acquisition protocols. While recent large-scale neuroimaging consortia have begun to address these challenges, such resources remain limited in the Canadian context, creating a critical gap. The Canadian Pediatric Imaging Platform (C-PIP) has developed a multisite neuroimaging framework across three of Canada's largest pediatric hospitals: Alberta Children's Hospital (Calgary), Centre Hospitalier Universitaire Sainte-Justine (Montreal), and the Hospital for Sick Children (Toronto). These three sites were united through a national initiative, leveraging high-performance MRI systems to accelerate Canadian neurodevelopmental research. In addition, C-PIP has implemented a centralized data sharing infrastructure to facilitate open science and collaborative research across institutions. Here, we describe the development and implementation of a multimodal MRI acquisition protocol designed to support multimodal longitudinal studies of typical and atypical brain development spanning infancy through adolescence. Within-site stability and cross-site stability of C-PIP core MRI sequences were evaluated using a travelling-participant study. The C-PIP MRI protocol establishes a harmonized, multisite imaging framework that supports large-scale investigations of pediatric brain development and disorders.
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BibTeX
@misc{singh2026canadian,
title = {{The Canadian Pediatric Imaging Platform (C-PIP) Reference Sample: Neuroimaging Protocol and Cross-site Validation for Harmonized Multimodal Pediatric Imaging}},
author = {M. Singh and S. Parimoo and V. Enguix and F. Cortese and M. Camacho and S. Spinney and S. J. Lynch and H. L. Carlson and L. M. Leijser and C. L. Tardif and I. R. Leppert and G. B. Pike and E. Kadalie and J. Near and C. Kumaragamage and R. Chitroda and M. L. Lauzon and K. Y. Manning and G. Varma and T. Paus and A. D. Harris and G. A. Lodygensky and M. H. Beauchamp and D. J. Mabott and D. C. Kopala-Sibley and J. A. . S. Vorstman and K. O. Yeates and P. D. Arnold and S. Jacquemont and D. S. Kadis and S. Lippe and L. Bellec and C. Lebel and P. Conrod and S. Bray and A. L. Wheeler},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.26.761379},
url = {https://www.biorxiv.org/content/10.64898/2026.10.26.761379v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - The Canadian Pediatric Imaging Platform (C-PIP) Reference Sample: Neuroimaging Protocol and Cross-site Validation for Harmonized Multimodal Pediatric Imaging
AU - M. Singh
AU - S. Parimoo
AU - V. Enguix
AU - F. Cortese
AU - M. Camacho
AU - S. Spinney
AU - S. J. Lynch
AU - H. L. Carlson
AU - L. M. Leijser
AU - C. L. Tardif
AU - I. R. Leppert
AU - G. B. Pike
AU - E. Kadalie
AU - J. Near
AU - C. Kumaragamage
AU - R. Chitroda
AU - M. L. Lauzon
AU - K. Y. Manning
AU - G. Varma
AU - T. Paus
AU - A. D. Harris
AU - G. A. Lodygensky
AU - M. H. Beauchamp
AU - D. J. Mabott
AU - D. C. Kopala-Sibley
AU - J. A. . S. Vorstman
AU - K. O. Yeates
AU - P. D. Arnold
AU - S. Jacquemont
AU - D. S. Kadis
AU - S. Lippe
AU - L. Bellec
AU - C. Lebel
AU - P. Conrod
AU - S. Bray
AU - A. L. Wheeler
PY - 2026
DA - 2026/10/26
PB - bioRxiv
DO - 10.64898/2026.10.26.761379
UR - https://www.biorxiv.org/content/10.64898/2026.10.26.761379v1
AB - Understanding how the human brain matures from infancy through adolescence is essential for identifying factors that influence health outcomes. Magnetic resonance imaging (MRI) provides powerful tools for characterizing structural, microstructural, functional, and metabolic aspects of brain development; however, many pediatric imaging studies are constrained by small sample sizes, limited geographic diversity, lack of longitudinal measurement, restricted age ranges, and heterogeneous acquisition protocols. While recent large-scale neuroimaging consortia have begun to address these challenges, such resources remain limited in the Canadian context, creating a critical gap. The Canadian Pediatric Imaging Platform (C-PIP) has developed a multisite neuroimaging framework across three of Canada's largest pediatric hospitals: Alberta Children's Hospital (Calgary), Centre Hospitalier Universitaire Sainte-Justine (Montreal), and the Hospital for Sick Children (Toronto). These three sites were united through a national initiative, leveraging high-performance MRI systems to accelerate Canadian neurodevelopmental research. In addition, C-PIP has implemented a centralized data sharing infrastructure to facilitate open science and collaborative research across institutions. Here, we describe the development and implementation of a multimodal MRI acquisition protocol designed to support multimodal longitudinal studies of typical and atypical brain development spanning infancy through adolescence. Within-site stability and cross-site stability of C-PIP core MRI sequences were evaluated using a travelling-participant study. The C-PIP MRI protocol establishes a harmonized, multisite imaging framework that supports large-scale investigations of pediatric brain development and disorders.
ER -