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PreprintCC BYbioRxiv

The p53-Mdm2 interaction through the lens of antithetic feedback

  • W. Jongeneel1
  • M. Scolamiero
  • K. H. Johansson
  1. 1KTH Royal Institute of Technology
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Abstract

We show that the p53-Mdm2 gene interaction can be understood as a form of antithetic feedback, but with mixed feedback loops. In particular, we show that this viewpoint sheds light on the emergence and robustness properties of p53's oscillatory behaviour, as observed experimentally.

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Cite

BibTeXRIS
BibTeX
@misc{jongeneel2026p53mdm2,
  title = {{The p53-Mdm2 interaction through the lens of antithetic feedback}},
  author = {W. Jongeneel and M. Scolamiero and K. H. Johansson},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.04.756583},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.04.756583v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - The p53-Mdm2 interaction through the lens of antithetic feedback
AU  - W. Jongeneel
AU  - M. Scolamiero
AU  - K. H. Johansson
PY  - 2026
DA  - 2026/10/04
PB  - bioRxiv
DO  - 10.64898/2026.10.04.756583
UR  - https://www.biorxiv.org/content/10.64898/2026.10.04.756583v1
AB  - We show that the p53-Mdm2 gene interaction can be understood as a form of antithetic feedback, but with mixed feedback loops. In particular, we show that this viewpoint sheds light on the emergence and robustness properties of p53's oscillatory behaviour, as observed experimentally.
ER  -