Bis(4-hydroxyphenyl) Sulfone Regulates Sperm Motility, Mitochondrial Activity, and Nitric Oxide Production in Boar Semen.
- 1College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.
- 2School of Information and Communication Technology, University of Tasmania, Hobart, TAS 7005, Australia.
Abstract
BPS is a substitute for bisphenol A, an endocrine disruptor. Our study aimed to evaluate the effects of BPS on sperm viability and motility, acrosomal membrane damage, mitochondrial activity, and NO production in boar semen. 0, 40.0, 80.0, and 100.0 μM BPS were treated in the boar semen. In the results, sperm viability did not change across any treatments. However, sperm motility was significantly decreased in the 100.0 μM BPS-treated groups (78.56%, p < 0.05) and progressive motility of sperm (60.24%, p < 0.05). Acrosomal membrane damage was not changed in the BPS-treated groups, but mitochondrial activity (58.85%, p < 0.05) of sperm was decreased in the 100.0 μM BPS-treated groups. The NO in the 100.0 μM BPS-treated sperm groups was increased (p < 0.05). Based on the results, we suggest that BPS elevates NO production, and the increased NO damages mitochondrial activity. Thus, BPS may directly regulate sperm motility, such as through oxidative stress.
Related
- Mitochondrial Calcium Uptake Promotes Mitochondrial Activation and Hyperactivated Motility During Human Sperm Capacitation
- ACAN regulates VSMC mitochondrial homeostasis through the YAP1/TAZ pathway and contributes to the onset and progression of aortic dissection
- CST1 Regulates ER-Mitochondrial Mg²⁺ Balance via MAGT1 to Promote Breast Cancer Metabolism and Growth.
- NuMA1 controls myonuclear motility in striated skeletal muscle through AMPK activity and is impaired in Duchenne muscular dystrophy
- The KLF4–SLC25A4 mitochondrial axis regulates ferroptotic vulnerability and sunitinib sensitivity in clear cell renal cell carcinoma
BibTeX
@article{lee2026bis4hydroxyphenyl,
title = {{Bis(4-hydroxyphenyl) Sulfone Regulates Sperm Motility, Mitochondrial Activity, and Nitric Oxide Production in Boar Semen.}},
author = {Seunghyung Lee and Sang-Hee Lee},
journal = {Animals : an open access journal from MDPI},
year = {2026},
month = oct,
doi = {10.3390/ani16193093},
url = {https://europepmc.org/article/MED/42883062},
note = {CC BY},
}
RIS
TY - JOUR
TI - Bis(4-hydroxyphenyl) Sulfone Regulates Sperm Motility, Mitochondrial Activity, and Nitric Oxide Production in Boar Semen.
AU - Seunghyung Lee
AU - Sang-Hee Lee
PY - 2026
DA - 2026/10/01
JO - Animals : an open access journal from MDPI
DO - 10.3390/ani16193093
UR - https://europepmc.org/article/MED/42883062
AB - BPS is a substitute for bisphenol A, an endocrine disruptor. Our study aimed to evaluate the effects of BPS on sperm viability and motility, acrosomal membrane damage, mitochondrial activity, and NO production in boar semen. 0, 40.0, 80.0, and 100.0 μM BPS were treated in the boar semen. In the results, sperm viability did not change across any treatments. However, sperm motility was significantly decreased in the 100.0 μM BPS-treated groups (78.56%, p < 0.05) and progressive motility of sperm (60.24%, p < 0.05). Acrosomal membrane damage was not changed in the BPS-treated groups, but mitochondrial activity (58.85%, p < 0.05) of sperm was decreased in the 100.0 μM BPS-treated groups. The NO in the 100.0 μM BPS-treated sperm groups was increased (p < 0.05). Based on the results, we suggest that BPS elevates NO production, and the increased NO damages mitochondrial activity. Thus, BPS may directly regulate sperm motility, such as through oxidative stress.
SN - 2076-2615
ER -