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Peer-reviewedCC BY-NC-NDDiabetology & Metabolic Syndrome

Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials

  • Vali Musazadeh1,2
  • Mehrnaz Morvaridi3
  • Seyed Mohammad Hosseini‐Roknabadi1
  • Mahsa Mahmoudinezhad4,5
  • A R Keshtkar Jafari6,7
  • Farzad Shidfar8
8 affiliations
  1. 1Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  2. 2Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
  3. 3Department of Nutrition, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
  4. 4Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran
  5. 5Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  6. 6Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [email protected]
  7. 7Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. [email protected]
  8. 8Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. [email protected]
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Abstract

BACKGROUND: Ginger is recognized as a valuable therapeutic and non-pharmacological intervention. Given its widespread use, clarifying its efficacy in modulating metabolic profiles is essential. This umbrella review evaluated the available evidence on the effectiveness of ginger in improving metabolic parameters. METHODS: A comprehensive systematic literature search was conducted in PubMed, Embase, Web of Science, Scopus, the Cochrane Library, Google Scholar up to January 2025 to identify systematic reviews and meta-analyses assessing ginger-related metabolic health outcomes. Extracted data included the number of studies, sample size, participants' mean age, dosage and duration of ginger administration, and effect sizes of reported outcomes. The methodological quality of included studies was appraised using the AMSTAR-2 tool. RESULTS: A total of 36 publications, encompassing 296 trials and 43,570 participants, were included. Ginger supplementation was consistently associated with significant reductions in C-reactive protein (range of reported WMD: - 0.42 to - 1.00 mg/L) and interleukin-6 (range of reported WMD: - 0.45 to - 2.26 pg/mL) across all included meta-analyses. Likewise, measures of oxidative stress and antioxidant status; including malondialdehyde, glutathione peroxidase, and total antioxidant capacity showed significant improvement. Most meta-analyses also reported favorable effects on lipid profiles triglycerides (range of reported WMD: - 0.61 to - 24.80 mg/dL), total cholesterol (range of reported WMD: - 0.33 to - 13.31 mg/dL), and LDL-C (range of reported WMD: - 0.30 to - 11.22 mg/dL), though results for high-density lipoprotein were limited. In addition, fasting blood sugar (range of reported WMD: - 0.68 to - 18.81 mg/dL) and HbA1c (range of reported WMD: - 0.27 to - 1.66%), HOMA-IR (range of reported WMD: - 0.54 to - 1.67) and insulin (range of reported WMD: - 0.54 to - 1.69) improved significantly in most meta-analyses. CONCLUSION: Overall, this umbrella review demonstrates that ginger supplementation yields clinically relevant benefits across a range of health outcomes, particularly in reducing inflammation, improving glycemic and lipid profiles, and supporting weight management.

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Cite

BibTeXRIS
BibTeX
@article{musazadeh2026ginger,
  title = {{Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials}},
  author = {Vali Musazadeh and Mehrnaz Morvaridi and Seyed Mohammad Hosseini‐Roknabadi and Mahsa Mahmoudinezhad and A R Keshtkar Jafari and Farzad Shidfar},
  journal = {Diabetology \& Metabolic Syndrome},
  year = {2026},
  month = may,
  doi = {10.1186/s13098-026-02150-y},
  url = {https://doi.org/10.1186/s13098-026-02150-y},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials
AU  - Vali Musazadeh
AU  - Mehrnaz Morvaridi
AU  - Seyed Mohammad Hosseini‐Roknabadi
AU  - Mahsa Mahmoudinezhad
AU  - A R Keshtkar Jafari
AU  - Farzad Shidfar
PY  - 2026
DA  - 2026/05/24
JO  - Diabetology & Metabolic Syndrome
DO  - 10.1186/s13098-026-02150-y
UR  - https://doi.org/10.1186/s13098-026-02150-y
AB  - BACKGROUND: Ginger is recognized as a valuable therapeutic and non-pharmacological intervention. Given its widespread use, clarifying its efficacy in modulating metabolic profiles is essential. This umbrella review evaluated the available evidence on the effectiveness of ginger in improving metabolic parameters. METHODS: A comprehensive systematic literature search was conducted in PubMed, Embase, Web of Science, Scopus, the Cochrane Library, Google Scholar up to January 2025 to identify systematic reviews and meta-analyses assessing ginger-related metabolic health outcomes. Extracted data included the number of studies, sample size, participants' mean age, dosage and duration of ginger administration, and effect sizes of reported outcomes. The methodological quality of included studies was appraised using the AMSTAR-2 tool. RESULTS: A total of 36 publications, encompassing 296 trials and 43,570 participants, were included. Ginger supplementation was consistently associated with significant reductions in C-reactive protein (range of reported WMD: - 0.42 to - 1.00 mg/L) and interleukin-6 (range of reported WMD: - 0.45 to - 2.26 pg/mL) across all included meta-analyses. Likewise, measures of oxidative stress and antioxidant status; including malondialdehyde, glutathione peroxidase, and total antioxidant capacity showed significant improvement. Most meta-analyses also reported favorable effects on lipid profiles triglycerides (range of reported WMD: - 0.61 to - 24.80 mg/dL), total cholesterol (range of reported WMD: - 0.33 to - 13.31 mg/dL), and LDL-C (range of reported WMD: - 0.30 to - 11.22 mg/dL), though results for high-density lipoprotein were limited. In addition, fasting blood sugar (range of reported WMD: - 0.68 to - 18.81 mg/dL) and HbA1c (range of reported WMD: - 0.27 to - 1.66%), HOMA-IR (range of reported WMD: - 0.54 to - 1.67) and insulin (range of reported WMD: - 0.54 to - 1.69) improved significantly in most meta-analyses. CONCLUSION: Overall, this umbrella review demonstrates that ginger supplementation yields clinically relevant benefits across a range of health outcomes, particularly in reducing inflammation, improving glycemic and lipid profiles, and supporting weight management.
SN  - 1758-5996
ER  -