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Peer-reviewedCC BYThe Journal of organic chemistry

Chemical Synthesis of Acybolins Reveals Their Antiproliferative Activity.

  • Raju Hazra1
  • Prabhakara R Tharra1
  • Jovita Mary1
  • Ondřej Naar2,3
  • Karel Souček2,3
  • Jakub Švenda1,3
  1. 1Department of Chemistry, Faculty of Science, Masaryk University, Brno625 00, Czech Republic.
  2. 2Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno612 00, Czech Republic.
  3. 3International Clinical Research Center, St. Anne's University Hospital, Brno656 91, Czech Republic.
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Abstract

An efficient synthetic access to the acybolin class of inducible secondary metabolites is being reported. The approach developed features coupling between the antibiotic (-)-bactobolin A and various acybolin side chains without the need for protecting groups. The biological evaluation of synthetic acybolins in human cancer cell cultures revealed their potent antiproliferative effects.

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Cite

BibTeXRIS
BibTeX
@article{hazra2026chemical,
  title = {{Chemical Synthesis of Acybolins Reveals Their Antiproliferative Activity.}},
  author = {Raju Hazra and Prabhakara R Tharra and Jovita Mary and Ondřej Naar and Karel Souček and Jakub Švenda},
  journal = {The Journal of organic chemistry},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.joc.6c01819},
  url = {https://europepmc.org/article/MED/42916960},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Chemical Synthesis of Acybolins Reveals Their Antiproliferative Activity.
AU  - Raju Hazra
AU  - Prabhakara R Tharra
AU  - Jovita Mary
AU  - Ondřej Naar
AU  - Karel Souček
AU  - Jakub Švenda
PY  - 2026
DA  - 2026/10/01
JO  - The Journal of organic chemistry
DO  - 10.1021/acs.joc.6c01819
UR  - https://europepmc.org/article/MED/42916960
AB  - An efficient synthetic access to the acybolin class of inducible secondary metabolites is being reported. The approach developed features coupling between the antibiotic (-)-bactobolin A and various acybolin side chains without the need for protecting groups. The biological evaluation of synthetic acybolins in human cancer cell cultures revealed their potent antiproliferative effects.
SN  - 0022-3263
SN  - 1520-6904
ER  -