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Peer-reviewedCC BYJournal of Clinical Investigation

Polyendocrine metabolic ovarian syndrome (PMOS)/polycystic ovary syndrome (PCOS): current and future trends

  • Jessica L. Chan1
  • Irene Masini1
  • Margareta Danuta Pisarska1
  1. 1Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA
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Abstract

Polycystic ovary syndrome (PCOS), also known as polyendocrine metabolic ovarian syndrome (PMOS), is the most common endocrinologic disorder to affect women. Despite this, the pathophysiology of the disease is not entirely known. This has hindered the diagnosis of the disease and appropriate treatment for millions of individuals. In this Review, we discuss the proposed pathophysiology of PCOS from a translational perspective. We review the existing diagnostic criteria of PCOS and current management strategies. Finally, we discuss the long-term health sequelae associated with PCOS, future directions, and areas of needed research in this often-overlooked disease.

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Cite

BibTeXRIS
BibTeX
@article{chan2026polyendocrine,
  title = {{Polyendocrine metabolic ovarian syndrome (PMOS)/polycystic ovary syndrome (PCOS): current and future trends}},
  author = {Jessica L. Chan and Irene Masini and Margareta Danuta Pisarska},
  journal = {Journal of Clinical Investigation},
  year = {2026},
  month = jun,
  doi = {10.1172/jci202824},
  url = {https://doi.org/10.1172/jci202824},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Polyendocrine metabolic ovarian syndrome (PMOS)/polycystic ovary syndrome (PCOS): current and future trends
AU  - Jessica L. Chan
AU  - Irene Masini
AU  - Margareta Danuta Pisarska
PY  - 2026
DA  - 2026/06/14
JO  - Journal of Clinical Investigation
DO  - 10.1172/jci202824
UR  - https://doi.org/10.1172/jci202824
AB  - Polycystic ovary syndrome (PCOS), also known as polyendocrine metabolic ovarian syndrome (PMOS), is the most common endocrinologic disorder to affect women. Despite this, the pathophysiology of the disease is not entirely known. This has hindered the diagnosis of the disease and appropriate treatment for millions of individuals. In this Review, we discuss the proposed pathophysiology of PCOS from a translational perspective. We review the existing diagnostic criteria of PCOS and current management strategies. Finally, we discuss the long-term health sequelae associated with PCOS, future directions, and areas of needed research in this often-overlooked disease.
SN  - 0021-9738
SN  - 1558-8238
ER  -