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Peer-reviewedCC BYThe European journal of neuroscience

Altered Timing of Self-Voice Processing in Parkinson's Disease.

  • Francisco Contreras-Ruston1,2,3,4
  • Antonio Criscuolo2,5
  • Antonio Callén6,7
  • David Cucurell3,8
  • Jordi Navarra3,9
  • Sonja A Kotz2,10
10 affiliations
  1. 1Center for Music in the Brain, Department of Clinical Medicine, Aarhus University and the Royal Academy of Music Aarhus/Aalborg, Aarhus, Denmark.
  2. 2Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
  3. 3Department of Cognition, Development and Educational Psychology, University of Barcelona, Barcelona, Spain.
  4. 4Speech-Language Pathology and Audiology Department -, Universidad de Valparaíso, San Felipe, Chile.
  5. 5Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
  6. 6Neurology Department, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain.
  7. 7Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
  8. 8Cognition and Brain Plasticity Unit, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain.
  9. 9Institute of Neurosciences, Universitat de Barcelona, Barcelona, Spain.
  10. 10Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
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Abstract

Parkinson's disease (PD) affects voice and speech production, often resulting in reduced vocal intensity and monotonous speech. Recent studies suggest that these changes can be partially explained by altered sensory feedback processing in speech production: individuals with PD (IwPD) may fail to monitor and adapt sensory feedback when producing speech. We investigated PD voice production using a voice playback paradigm and focused on the sensory attenuation typically observed in event-related responses (ERPs) to the self-generated voice. When sensory feedback is intact, the P50, N100, and P200 responses to a self-generated voice are attenuated compared to an externally generated voice. Twenty-three IwPD and 23 matched healthy controls (HCs) completed the voice playback study with three conditions: self-generated voice (auditory-motor [AMC]), externally generated voice (auditory-only [AOC]), and motor-only. Linear mixed models assessed group differences in ERP morphology. Groups differed in the N100 latency response: IwPD showed a greater shift in latency between AMC and AOC than healthy controls. Regarding the P200, a significant group-by-condition interaction indicated that IwPD, unlike healthy controls, produced larger amplitudes for the self-generated than the passively listened to voice. Taken together, these findings suggest that the processing of one's own voice in IwPD is altered in terms of temporal precision rather than in the N100 suppression effect per se. This effect was accompanied by an enhanced P200 attentional response. These response patterns in IwPD are indicative of likely progressing difficulties in regulating one's own voice, characteristic of Parkinson's disease.

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Cite

BibTeXRIS
BibTeX
@article{contrerasruston2026altered,
  title = {{Altered Timing of Self-Voice Processing in Parkinson's Disease.}},
  author = {Francisco Contreras-Ruston and Antonio Criscuolo and Antonio Callén and David Cucurell and Jordi Navarra and Sonja A Kotz},
  journal = {The European journal of neuroscience},
  year = {2026},
  month = oct,
  doi = {10.1111/ejn.70700},
  url = {https://europepmc.org/article/MED/42875899},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Altered Timing of Self-Voice Processing in Parkinson's Disease.
AU  - Francisco Contreras-Ruston
AU  - Antonio Criscuolo
AU  - Antonio Callén
AU  - David Cucurell
AU  - Jordi Navarra
AU  - Sonja A Kotz
PY  - 2026
DA  - 2026/10/01
JO  - The European journal of neuroscience
DO  - 10.1111/ejn.70700
UR  - https://europepmc.org/article/MED/42875899
AB  - Parkinson's disease (PD) affects voice and speech production, often resulting in reduced vocal intensity and monotonous speech. Recent studies suggest that these changes can be partially explained by altered sensory feedback processing in speech production: individuals with PD (IwPD) may fail to monitor and adapt sensory feedback when producing speech. We investigated PD voice production using a voice playback paradigm and focused on the sensory attenuation typically observed in event-related responses (ERPs) to the self-generated voice. When sensory feedback is intact, the P50, N100, and P200 responses to a self-generated voice are attenuated compared to an externally generated voice. Twenty-three IwPD and 23 matched healthy controls (HCs) completed the voice playback study with three conditions: self-generated voice (auditory-motor [AMC]), externally generated voice (auditory-only [AOC]), and motor-only. Linear mixed models assessed group differences in ERP morphology. Groups differed in the N100 latency response: IwPD showed a greater shift in latency between AMC and AOC than healthy controls. Regarding the P200, a significant group-by-condition interaction indicated that IwPD, unlike healthy controls, produced larger amplitudes for the self-generated than the passively listened to voice. Taken together, these findings suggest that the processing of one's own voice in IwPD is altered in terms of temporal precision rather than in the N100 suppression effect per se. This effect was accompanied by an enhanced P200 attentional response. These response patterns in IwPD are indicative of likely progressing difficulties in regulating one's own voice, characteristic of Parkinson's disease.
SN  - 0953-816X
SN  - 1460-9568
ER  -