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Peer-reviewedCC BY-NC-ND 4.0JACC Case Reports

Development and Evaluation of Multimodal Universal CPR AI Assistance and Response Engine (U-CARE)

4 affiliations
  1. 1Stanford University Online High School, Redwood City, California, USA
  2. 2Research Fellow, GSE, Stanford University, Stanford, California, USA
  3. 3Center for Precision Medicine, University of California Davis Health, Davis, California, USA
  4. 4Department of Anesthesiology, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

Background: Each year, 350,000 people in the United States experience out-of-hospital cardiac arrest, and 90% do not survive. Early cardiopulmonary resuscitation (CPR) can double or triple survival rates.

Project Rationale: Bystander CPR is performed correctly in fewer than 40% of cases, with major challenges persisting: lack of widespread training, decision paralysis, and recall bias during an emergency.

Project Summary: Universal CPR Assistance and Response Engine (U-CARE) is a low-cost smartphone-based system that serves as a universal CPR guide to address these challenges. A large language model–powered verbal guidance system provides objective next-best steps multilingually, coupled with a computer vision model that continuously assesses CPR technique. U-CARE was evaluated using holistic large language model evaluation and computer vision metrics, and outperformed out-of-the-box frontier models on relevance and safety in human evaluation, demonstrating its viability for real-time feedback.

Take-Home Message: U-CARE demonstrates the feasibility of a smartphone-based multimodal CPR feedback and response agent for emergency and training guidance.

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BibTeX
@article{atreja2026development,
  title = {{Development and Evaluation of Multimodal Universal CPR AI Assistance and Response Engine (U-CARE)}},
  author = {Aarit Atreja and Utkarsh Contractor and Dharan Jaisankar and Piyush Mathur},
  journal = {JACC Case Reports},
  year = {2026},
  month = sep,
  doi = {10.1016/j.jaccas.2026.110026},
  url = {https://doi.org/10.1016/j.jaccas.2026.110026},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Development and Evaluation of Multimodal Universal CPR AI Assistance and Response Engine (U-CARE)
AU  - Aarit Atreja
AU  - Utkarsh Contractor
AU  - Dharan Jaisankar
AU  - Piyush Mathur
PY  - 2026
DA  - 2026/09/16
JO  - JACC Case Reports
DO  - 10.1016/j.jaccas.2026.110026
UR  - https://doi.org/10.1016/j.jaccas.2026.110026
AB  - Background: Each year, 350,000 people in the United States experience out-of-hospital cardiac arrest, and 90% do not survive. Early cardiopulmonary resuscitation (CPR) can double or triple survival rates.  Project Rationale: Bystander CPR is performed correctly in fewer than 40% of cases, with major challenges persisting: lack of widespread training, decision paralysis, and recall bias during an emergency.  Project Summary: Universal CPR Assistance and Response Engine (U-CARE) is a low-cost smartphone-based system that serves as a universal CPR guide to address these challenges. A large language model–powered verbal guidance system provides objective next-best steps multilingually, coupled with a computer vision model that continuously assesses CPR technique. U-CARE was evaluated using holistic large language model evaluation and computer vision metrics, and outperformed out-of-the-box frontier models on relevance and safety in human evaluation, demonstrating its viability for real-time feedback.  Take-Home Message: U-CARE demonstrates the feasibility of a smartphone-based multimodal CPR feedback and response agent for emergency and training guidance.
SN  - 2666-0849
ER  -