Pleiotrophin Exerts Its Migration and Invasion Effect through the Neuropilin-1 Pathway
Abstract
Pleiotrophin (PTN) is a pleiotropic growth factor that exhibits angiogenic properties and is involved in tumor growth and metastasis. Although it has been shown that PTN is expressed in tumor cells, few studies have investigated its receptors and their involvement in cell migration and invasion. Neuropilin-1 (NRP-1) is a receptor for multiple growth factors that mediates cell motility and plays an important role in angiogenesis and tumor progression. Here we provide evidence for the first time that NRP-1 is crucial for biological activities of PTN. We found that PTN interacted directly with NRP-1 through its thrombospondin type-I repeat domains. Importantly, binding of PTN to NRP-1 stimulated the internalization and recycling of NRP-1 at the cell surface. Invalidation of NRP-1 by RNA interference in human carcinoma cells inhibited PTN-induced intracellular signaling of the serine-threonine kinase, mitogen-activated protein MAP kinase, and focal adhesion kinase pathways. Accordingly, NRP-1 silencing or blocking by antibody inhibited PTN-induced human umbilical vein endothelial cell migration and tumor cell invasion. These results suggest that NRP-1/PTN interaction provides a novel mechanism for controlling the response of endothelial and tumoral cells to PTN and may explain, at least in part, how PTN contributes to tumor angiogenesis and cancer progression.
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BibTeX
@article{elahouel2026pleiotrophin,
title = {{Pleiotrophin Exerts Its Migration and Invasion Effect through the Neuropilin-1 Pathway}},
author = {Rania Elahouel and Charly Blanc and Gilles Carpentier and Sophie Frechault and Ilaria Cascone and Damien Destouches and Jean Delbé and José Courty and Yamina Hamma-Kourbali},
journal = {Neoplasia},
year = {2026},
month = oct,
doi = {10.1016/j.neo.2015.07.007},
url = {https://hal.science/hal-05801789v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Pleiotrophin Exerts Its Migration and Invasion Effect through the Neuropilin-1 Pathway
AU - Rania Elahouel
AU - Charly Blanc
AU - Gilles Carpentier
AU - Sophie Frechault
AU - Ilaria Cascone
AU - Damien Destouches
AU - Jean Delbé
AU - José Courty
AU - Yamina Hamma-Kourbali
PY - 2026
DA - 2026/10/15
JO - Neoplasia
DO - 10.1016/j.neo.2015.07.007
UR - https://hal.science/hal-05801789v1
AB - Pleiotrophin (PTN) is a pleiotropic growth factor that exhibits angiogenic properties and is involved in tumor growth and metastasis. Although it has been shown that PTN is expressed in tumor cells, few studies have investigated its receptors and their involvement in cell migration and invasion. Neuropilin-1 (NRP-1) is a receptor for multiple growth factors that mediates cell motility and plays an important role in angiogenesis and tumor progression. Here we provide evidence for the first time that NRP-1 is crucial for biological activities of PTN. We found that PTN interacted directly with NRP-1 through its thrombospondin type-I repeat domains. Importantly, binding of PTN to NRP-1 stimulated the internalization and recycling of NRP-1 at the cell surface. Invalidation of NRP-1 by RNA interference in human carcinoma cells inhibited PTN-induced intracellular signaling of the serine-threonine kinase, mitogen-activated protein MAP kinase, and focal adhesion kinase pathways. Accordingly, NRP-1 silencing or blocking by antibody inhibited PTN-induced human umbilical vein endothelial cell migration and tumor cell invasion. These results suggest that NRP-1/PTN interaction provides a novel mechanism for controlling the response of endothelial and tumoral cells to PTN and may explain, at least in part, how PTN contributes to tumor angiogenesis and cancer progression.
SN - 1522-8002
SN - 1476-5586
ER -