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Peer-reviewedCC BY 4.0Current Research in Insect Science

Sublethal chlorpyrifos exposure induces intergenerational fitness costs and mitochondrial alterations in Blattella germanica

  • Xin Li1
  • Jiang-Ling Chen1
  • Zi-Han Xu1
  • Jun Tao1
  • Yi Chen1
  • Shu-Lin He1
  • Fei Li1
  • Cao Zhou1
  1. 1Chongqing Key Laboratory of Vector Control and Utilization, Institute of Entomology and Molecular Biology, Chongqing Normal University, Chongqing, China
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Abstract

Under real-world conditions, the German cockroach Blattella germanica is frequently exposed to sublethal insecticide concentrations, yet the long-term consequences for population dynamics remain poorly understood. Here, we investigated the intergenerational effects of sublethal chlorpyrifos exposure in this urban pest. Newly emerged adults were treated with LD10 or LD30, and fitness-related traits and molecular responses were evaluated in the F0 and F1 generations. Sublethal exposure reduced fecundity and longevity in the F0 generation. Parental exposure also induced intergenerational effects in the F1 generation, including prolonged development, reduced survival, altered reproductive timing, and a decreased net reproductive rate. Population projection analysis indicated that LD10 suppressed long-term population growth. Chlorpyrifos further induced dose-dependent and intergenerational changes in detoxification-related genes, particularly BgCYP6ER1 and BgCYP6J1. In addition, mtDNA copy number increased under LD30, whereas BgCytb transcription was downregulated in the F1 generation, suggesting mitochondrial dysregulation under sublethal stress. These findings demonstrate that sublethal chlorpyrifos exposure can induce intergenerational effects on fitness-related traits and molecular responses. and highlight potential implications for pesticide risk assessment and resistance management.

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Cite

BibTeXRIS
BibTeX
@article{li2026sublethal,
  title = {{Sublethal chlorpyrifos exposure induces intergenerational fitness costs and mitochondrial alterations in Blattella germanica}},
  author = {Xin Li and Jiang-Ling Chen and Zi-Han Xu and Jun Tao and Yi Chen and Shu-Lin He and Fei Li and Cao Zhou},
  journal = {Current Research in Insect Science},
  year = {2026},
  month = oct,
  doi = {10.1016/j.cris.2026.100136},
  url = {https://doi.org/10.1016/j.cris.2026.100136},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Sublethal chlorpyrifos exposure induces intergenerational fitness costs and mitochondrial alterations in Blattella germanica
AU  - Xin Li
AU  - Jiang-Ling Chen
AU  - Zi-Han Xu
AU  - Jun Tao
AU  - Yi Chen
AU  - Shu-Lin He
AU  - Fei Li
AU  - Cao Zhou
PY  - 2026
DA  - 2026/10/23
JO  - Current Research in Insect Science
DO  - 10.1016/j.cris.2026.100136
UR  - https://doi.org/10.1016/j.cris.2026.100136
AB  - Under real-world conditions, the German cockroach Blattella germanica is frequently exposed to sublethal insecticide concentrations, yet the long-term consequences for population dynamics remain poorly understood. Here, we investigated the intergenerational effects of sublethal chlorpyrifos exposure in this urban pest. Newly emerged adults were treated with LD10 or LD30, and fitness-related traits and molecular responses were evaluated in the F0 and F1 generations. Sublethal exposure reduced fecundity and longevity in the F0 generation. Parental exposure also induced intergenerational effects in the F1 generation, including prolonged development, reduced survival, altered reproductive timing, and a decreased net reproductive rate. Population projection analysis indicated that LD10 suppressed long-term population growth. Chlorpyrifos further induced dose-dependent and intergenerational changes in detoxification-related genes, particularly BgCYP6ER1 and BgCYP6J1. In addition, mtDNA copy number increased under LD30, whereas BgCytb transcription was downregulated in the F1 generation, suggesting mitochondrial dysregulation under sublethal stress. These findings demonstrate that sublethal chlorpyrifos exposure can induce intergenerational effects on fitness-related traits and molecular responses. and highlight potential implications for pesticide risk assessment and resistance management.
SN  - 2666-5158
ER  -