Recent Advances in Site‐ and Stereocontrolled Selective Light‐Mediated Functionalizations of Monosaccharide Derivatives
Abstract
Recent advances in visible‐light photochemistry have profoundly transformed the selective functionalization of carbohydrates, offering straightforward alternatives to classical protecting‐group‐based strategies. This Review highlights the emergence of photochemical methods enabling site‐ and stereocontrolled editing of monosaccharide derivatives through radical‐mediated processes. Particular emphasis is placed on minimally protected and unprotected substrates, for which selective C─H activation, epimerization, bond‐forming reactions, and skeletal editing can now be achieved under mild conditions. Recent developments in photoredox catalysis involving hydrogen‐atom transfer, electron donor–acceptor complexes, and metallaphotoredox catalysis are discussed, together with the mechanistic principles governing regio‐ and stereoselectivity.
Related
- Carbazole derivatives as privileged scaffolds for kinase inhibition: advances in design, therapeutic applications and mechanisms
- Recent advances in the synthesis, structural diversification, and biological evaluation of sulfamethoxazole derivatives.
- Selective fluorescence turn-on detection of methylglyoxal using N-substituted NBD derivatives
- “Design, Synthesis, and Biological Evaluation of Novel Oxindole-Based Derivatives as Potent and Selective Antileukemic Agents.”
- Carltonine B derivatives: Synthesis and structure-activity relationship insights for selective butyrylcholinesterase inhibition
BibTeX
@article{lefebvre2026recent,
title = {{Recent Advances in Site‐ and Stereocontrolled Selective Light‐Mediated Functionalizations of Monosaccharide Derivatives}},
author = {Corentin Lefebvre and Norbert Hoffmann},
journal = {ChemPhotoChem},
year = {2026},
month = oct,
doi = {10.1002/cptc.70314},
url = {https://hal.science/hal-05841916v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Recent Advances in Site‐ and Stereocontrolled Selective Light‐Mediated Functionalizations of Monosaccharide Derivatives
AU - Corentin Lefebvre
AU - Norbert Hoffmann
PY - 2026
DA - 2026/10/28
JO - ChemPhotoChem
DO - 10.1002/cptc.70314
UR - https://hal.science/hal-05841916v1
AB - Recent advances in visible‐light photochemistry have profoundly transformed the selective functionalization of carbohydrates, offering straightforward alternatives to classical protecting‐group‐based strategies. This Review highlights the emergence of photochemical methods enabling site‐ and stereocontrolled editing of monosaccharide derivatives through radical‐mediated processes. Particular emphasis is placed on minimally protected and unprotected substrates, for which selective C─H activation, epimerization, bond‐forming reactions, and skeletal editing can now be achieved under mild conditions. Recent developments in photoredox catalysis involving hydrogen‐atom transfer, electron donor–acceptor complexes, and metallaphotoredox catalysis are discussed, together with the mechanistic principles governing regio‐ and stereoselectivity.
SN - 2367-0932
ER -