In vitro and in vivo studies of the endocrine disrupting potency of cadmium in roach (Rutilus rutilus) liver
Abstract
Cadmium has been reported to exert estrogenic, antiestrogenic or both effects in vertebrate species. To elucidate the endocrine disrupting action of CdCl2, ex vivo and in vivo experiments were performed in roach (Rutilus rutilus). Roach liver explants were exposed to a range of CdCl2 concentrations alone (0.1–50 μM) or with an effective concentration (100 nM) of 17β-estradiol (E2). In addition, juvenile roach were intraperitoneally injected with CdCl2 (0.1–2.5 mg/kg) with or without 1 mg E2/kg. Subsequent analysis evaluated the effect of CdCl2 on vitellogenin (VTG) synthesis both at the mRNA and protein level, on estrogen receptors (erα and erβ1) and on androgen receptor (ar) mRNA expression. Ex vivo and in vivo experiments indicated that CdCl2 is strongly anti-estrogenic as, when co-exposed to E2, CdCl2 significantly inhibited VTG production as well as vtg and erα mRNA expressions. Moreover, CdCl2 compromised the E2-mediated induction of the ar mRNA expression in vivo.
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BibTeX
@article{gerbron2026vitro,
title = {{In vitro and in vivo studies of the endocrine disrupting potency of cadmium in roach (Rutilus rutilus) liver}},
author = {Marie Gerbron and Perrine Geraudie and Benoit Xuereb and Sabine Marie and Christophe Minier},
journal = {Marine Pollution Bulletin},
year = {2026},
month = sep,
doi = {10.1016/j.marpolbul.2015.03.043},
url = {https://hal.science/hal-01918576v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - In vitro and in vivo studies of the endocrine disrupting potency of cadmium in roach (Rutilus rutilus) liver
AU - Marie Gerbron
AU - Perrine Geraudie
AU - Benoit Xuereb
AU - Sabine Marie
AU - Christophe Minier
PY - 2026
DA - 2026/09/15
JO - Marine Pollution Bulletin
DO - 10.1016/j.marpolbul.2015.03.043
UR - https://hal.science/hal-01918576v1
AB - Cadmium has been reported to exert estrogenic, antiestrogenic or both effects in vertebrate species. To elucidate the endocrine disrupting action of CdCl2, ex vivo and in vivo experiments were performed in roach (Rutilus rutilus). Roach liver explants were exposed to a range of CdCl2 concentrations alone (0.1–50 μM) or with an effective concentration (100 nM) of 17β-estradiol (E2). In addition, juvenile roach were intraperitoneally injected with CdCl2 (0.1–2.5 mg/kg) with or without 1 mg E2/kg. Subsequent analysis evaluated the effect of CdCl2 on vitellogenin (VTG) synthesis both at the mRNA and protein level, on estrogen receptors (erα and erβ1) and on androgen receptor (ar) mRNA expression. Ex vivo and in vivo experiments indicated that CdCl2 is strongly anti-estrogenic as, when co-exposed to E2, CdCl2 significantly inhibited VTG production as well as vtg and erα mRNA expressions. Moreover, CdCl2 compromised the E2-mediated induction of the ar mRNA expression in vivo.
SN - 0025-326X
SN - 1879-3363
ER -