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PreprintCC BYbioRxiv

Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats

  • C. A. Turner
  • N. Morales Pagan
  • D. Pereira
  • E. Y. Sun
  • R. E. Himelhoch
  • S. E. Chang
  • S. B. Flagel1
  1. 1University of Michigan
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Abstract

Following cocaine self-administration, male and female rats received daily semaglutide during a 30-day abstinence period before cue- and cocaine-induced reinstatement tests. Semaglutide attenuated cue-induced reinstatement and cocaine-induced stereotypy, although operant responding was elevated following cocaine priming. These findings support further investigation of semaglutide as a treatment for cocaine use disorder.

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Cite

BibTeXRIS
BibTeX
@misc{turner2026chronic,
  title = {{Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats}},
  author = {C. A. Turner and N. Morales Pagan and D. Pereira and E. Y. Sun and R. E. Himelhoch and S. E. Chang and S. B. Flagel},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.21.753157},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.21.753157v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats
AU  - C. A. Turner
AU  - N. Morales Pagan
AU  - D. Pereira
AU  - E. Y. Sun
AU  - R. E. Himelhoch
AU  - S. E. Chang
AU  - S. B. Flagel
PY  - 2026
DA  - 2026/09/21
PB  - bioRxiv
DO  - 10.64898/2026.09.21.753157
UR  - https://www.biorxiv.org/content/10.64898/2026.09.21.753157v1
AB  - Following cocaine self-administration, male and female rats received daily semaglutide during a 30-day abstinence period before cue- and cocaine-induced reinstatement tests. Semaglutide attenuated cue-induced reinstatement and cocaine-induced stereotypy, although operant responding was elevated following cocaine priming. These findings support further investigation of semaglutide as a treatment for cocaine use disorder.
ER  -