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Peer-reviewedCC BYmicroPublication Biology

The methyltransferase Rrp8 is a positive regulator of autophagy flux in Saccharomyces cerevisiae

  • Swaroopa Badenahalli Narasimhaiah1
  • Elizabeth Delorme-Axford1
  1. 1Biological Sciences, Oakland University, Rochester, MI, United States
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Abstract

Macroautophagy (hereafter referred to as autophagy) is a dynamic pathway of cellular degradation and recycling that is conserved from yeast to humans. The products of autophagic degradation may be used for anabolic reactions during nutrient-limited conditions. Thus, autophagy serves both metabolic and quality control functions. However, the role of nucleolar proteins in autophagy remains largely unexplored. Here we identify Ribosomal RNA processing 8 (Rrp8) as a positive regulator of autophagy flux in the yeast Saccharomyces cerevisiae. Our work provides insight into the role of the conserved nucleolar protein Rrp8 in regulating cellular responses to starvation.

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Cite

BibTeXRIS
BibTeX
@article{narasimhaiah2026methyltransferase,
  title = {{The methyltransferase Rrp8 is a positive regulator of autophagy flux in Saccharomyces cerevisiae}},
  author = {Swaroopa Badenahalli Narasimhaiah and Elizabeth Delorme-Axford},
  journal = {microPublication Biology},
  year = {2026},
  month = aug,
  doi = {10.17912/micropub.biology.002252},
  url = {https://doi.org/10.17912/micropub.biology.002252},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The methyltransferase Rrp8 is a positive regulator of autophagy flux in Saccharomyces cerevisiae
AU  - Swaroopa Badenahalli Narasimhaiah
AU  - Elizabeth Delorme-Axford
PY  - 2026
DA  - 2026/08/01
JO  - microPublication Biology
DO  - 10.17912/micropub.biology.002252
UR  - https://doi.org/10.17912/micropub.biology.002252
AB  - Macroautophagy (hereafter referred to as autophagy) is a dynamic pathway of cellular degradation and recycling that is conserved from yeast to humans. The products of autophagic degradation may be used for anabolic reactions during nutrient-limited conditions. Thus, autophagy serves both metabolic and quality control functions. However, the role of nucleolar proteins in autophagy remains largely unexplored. Here we identify Ribosomal RNA processing 8 (Rrp8) as a positive regulator of autophagy flux in the yeast Saccharomyces cerevisiae. Our work provides insight into the role of the conserved nucleolar protein Rrp8 in regulating cellular responses to starvation.
SN  - 2578-9430
ER  -