Blinking membrane patterns induced by protein binding/unbinding
Abstract
Nonequilibrium membrane pattern formation is studied using meshless membrane simulation. Bound proteins are considered to have two states that generate different membrane spontaneous curvatures. Protein binding and unbinding occur cyclically owing to chemical potential differences, as an off-lattice active Potts model. It is found that this cyclic binding/unbinding can induce blinking domains, with oscillating size: convex domains of the proteins with a higher spontaneous curvature grow, and subsequently, the proteins change to the other state with a lower spontaneous curvature, resulting in domain shrinkage. These processes repeat. In thermal equilibrium, hexagonal convex domains are formed by the competition between bending and surface tension energies, so that they are stably formed only under positive surface tension. However, blinking domains can form even in tensionless membranes.
Versions
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BibTeX
@misc{noguchi2026blinking,
title = {{Blinking membrane patterns induced by protein binding/unbinding}},
author = {Hiroshi Noguchi},
howpublished = {arXiv},
year = {2026},
month = oct,
doi = {10.48550/arxiv.2608.13016},
eprint = {2608.13016},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2608.13016},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - Blinking membrane patterns induced by protein binding/unbinding
AU - Hiroshi Noguchi
PY - 2026
DA - 2026/10/16
PB - arXiv
DO - 10.48550/arxiv.2608.13016
UR - https://arxiv.org/abs/2608.13016
AB - Nonequilibrium membrane pattern formation is studied using meshless membrane simulation. Bound proteins are considered to have two states that generate different membrane spontaneous curvatures. Protein binding and unbinding occur cyclically owing to chemical potential differences, as an off-lattice active Potts model. It is found that this cyclic binding/unbinding can induce blinking domains, with oscillating size: convex domains of the proteins with a higher spontaneous curvature grow, and subsequently, the proteins change to the other state with a lower spontaneous curvature, resulting in domain shrinkage. These processes repeat. In thermal equilibrium, hexagonal convex domains are formed by the competition between bending and surface tension energies, so that they are stably formed only under positive surface tension. However, blinking domains can form even in tensionless membranes.
ER -