A Case of Idiopathic Hypereosinophilic Syndrome With High WT1 (Wilms' Tumor Gene) mRNA.

Abstract

A 59-year-old man presented with fever, erythema multiforme, and pancreatic swelling. Laboratory tests revealed severe peripheral hypereosinophilia without a history of relevant medication or evidence of infection. Bone marrow analysis revealed no blast proliferation or leukemia-associated fusion genes. Notably, Wilms' tumor gene (WT1) mRNA was markedly elevated at 26,000 copies/µg RNA. Idiopathic hypereosinophilic syndrome was diagnosed, and oral corticosteroid therapy was initiated, resulting in rapid and complete improvement. This case highlights a rare presentation of idiopathic hypereosinophilic syndrome with high WT1 mRNA, which helps in the differential diagnosis between secondary (reactive) and idiopathic hypereosinophilic syndrome (HES).

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BibTeX RIS

BibTeX

@article{tamai2026case,
  title = {{A Case of Idiopathic Hypereosinophilic Syndrome With High WT1 (Wilms' Tumor Gene) mRNA.}},
  author = {Keiichi Tamai and Yuzo Suzuki and Teie Egawa and Hiroki Kikuchi and Shiho Uchiyama and Ryosuke Kikuchi and Hiroshi Yokoyama},
  journal = {Cureus},
  year = {2026},
  month = sep,
  doi = {10.7759/cureus.116864},
  url = {https://europepmc.org/article/MED/42927137},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - A Case of Idiopathic Hypereosinophilic Syndrome With High WT1 (Wilms' Tumor Gene) mRNA.
AU  - Keiichi Tamai
AU  - Yuzo Suzuki
AU  - Teie Egawa
AU  - Hiroki Kikuchi
AU  - Shiho Uchiyama
AU  - Ryosuke Kikuchi
AU  - Hiroshi Yokoyama
PY  - 2026
DA  - 2026/09/24
JO  - Cureus
DO  - 10.7759/cureus.116864
UR  - https://europepmc.org/article/MED/42927137
AB  - A 59-year-old man presented with fever, erythema multiforme, and pancreatic swelling. Laboratory tests revealed severe peripheral hypereosinophilia without a history of relevant medication or evidence of infection. Bone marrow analysis revealed no blast proliferation or leukemia-associated fusion genes. Notably, Wilms' tumor gene (WT1) mRNA was markedly elevated at 26,000 copies/µg RNA. Idiopathic hypereosinophilic syndrome was diagnosed, and oral corticosteroid therapy was initiated, resulting in rapid and complete improvement. This case highlights a rare presentation of idiopathic hypereosinophilic syndrome with high WT1 mRNA, which helps in the differential diagnosis between secondary (reactive) and idiopathic hypereosinophilic syndrome (HES).
SN  - 2168-8184
ER  -

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