Targeting Specific Sirtuin Modulation: Emerging Therapeutic Strategies for Healthy Cognitive Ageing and Potential Implications for Alzheimer’s Disease
4 affiliations
- 1School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia
- 2Healthy Brain and Mind Research Centre, Australian Catholic University, Melbourne, VIC 3065, Australia
- 3Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Brisbane, QLD 4014, Australia
- 4School of Medical, Indigenous and Health Science, University of Wollongong, Wollongong, NSW 2522, Australia
Abstract
Nicotinamide adenine dinucleotide (+)-dependent class III histone deacetylases, widely known as sirtuins (SIRTs), have been found to play key functions in a wide range of biological processes implicated in ageing processes. The downregulation of some specific SIRTs was reported in ageing and in some neurological diseases such as Alzheimer’s disease. SIRT modulator factors, such as diet, exercise and various natural compounds, have recently emerged as a potential new avenue of therapy to modify the progression of Alzheimer’s disease and delay some ageing effects. This review synthesises recent advances in the understanding of the modulatory effects of SIRTs in the context of healthy ageing with a particular focus on cognitive function and implications for Alzheimer’s disease.
Related
- Targeting tetrahydrobiopterin metabolism in diabetic neuropathic pain: mechanisms, implications, and therapeutic strategies.
- Targeting the NLRP3 inflammasome in rheumatoid arthritis fibroblast-like synoviocytes: pathogenic mechanisms, therapeutic strategies, and translational perspectives
- Therapeutic potential of natural product polysaccharides in hepatocellular carcinoma: from microenvironment modulation to combination strategies
- Nano-formulations in therapeutic strategies targeting cancer ferroptosis
- Multi-target network modulation of Traditional Chinese Medicine in radiation enteropathy: mechanistic insights and therapeutic implications.
BibTeX
@article{mcdermott2026targeting,
title = {{Targeting Specific Sirtuin Modulation: Emerging Therapeutic Strategies for Healthy Cognitive Ageing and Potential Implications for Alzheimer’s Disease}},
author = {Charlotte McDermott and Michael H. Cole and Madison Pearson and Pia Winberg and Francesca Fernandez},
journal = {Molecules (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/molecules31193528},
url = {https://europepmc.org/article/PMC/PMC13666682},
note = {CC BY},
}
RIS
TY - JOUR
TI - Targeting Specific Sirtuin Modulation: Emerging Therapeutic Strategies for Healthy Cognitive Ageing and Potential Implications for Alzheimer’s Disease
AU - Charlotte McDermott
AU - Michael H. Cole
AU - Madison Pearson
AU - Pia Winberg
AU - Francesca Fernandez
PY - 2026
DA - 2026/10/01
JO - Molecules (Basel, Switzerland)
DO - 10.3390/molecules31193528
UR - https://europepmc.org/article/PMC/PMC13666682
AB - Nicotinamide adenine dinucleotide (+)-dependent class III histone deacetylases, widely known as sirtuins (SIRTs), have been found to play key functions in a wide range of biological processes implicated in ageing processes. The downregulation of some specific SIRTs was reported in ageing and in some neurological diseases such as Alzheimer’s disease. SIRT modulator factors, such as diet, exercise and various natural compounds, have recently emerged as a potential new avenue of therapy to modify the progression of Alzheimer’s disease and delay some ageing effects. This review synthesises recent advances in the understanding of the modulatory effects of SIRTs in the context of healthy ageing with a particular focus on cognitive function and implications for Alzheimer’s disease.
SN - 1420-3049
ER -