Unlocking the Full Potential of Taylor Dispersion Analysis Through Advanced Detection
Abstract
Today, pharmaceutical sciences rely on a wide range of innovative therapeutics of varying sizes: nanoparticles, proteins, antibodies, and nanocarriers for drug delivery. Measuring their size is one of the crucial parameters in their characterization, to ensure drug safety, stability, and effectiveness. Over the past two decades, Taylor Dispersion Analysis has emerged as an important sizing method. Its scope of application is perfectly suited to the sizes of these therapeutics. By design, it can be coupled with a wide range of detectors, and extensive research has been conducted in this field. In this review, we will present an overview of the studies conducted, and discuss how the application drives the choice of one detector or another (size measurement, aggregation studies, interaction studies, and other analyses, performed in both simple biological buffers and in more complex media, particularly serum) and makes Taylor Dispersion Analysis a highly versatile tool.
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BibTeX
@article{laoufi2026unlocking,
title = {{Unlocking the Full Potential of Taylor Dispersion Analysis Through Advanced Detection}},
author = {Rami Laoufi and Agnès Hagège},
journal = {Pharmaceuticals},
year = {2026},
month = sep,
doi = {10.3390/ph19101543},
eprint = {2610.30039},
archivePrefix = {arXiv},
url = {https://hal.science/hal-05829538v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Unlocking the Full Potential of Taylor Dispersion Analysis Through Advanced Detection
AU - Rami Laoufi
AU - Agnès Hagège
PY - 2026
DA - 2026/09/29
JO - Pharmaceuticals
DO - 10.3390/ph19101543
UR - https://hal.science/hal-05829538v1
AB - Today, pharmaceutical sciences rely on a wide range of innovative therapeutics of varying sizes: nanoparticles, proteins, antibodies, and nanocarriers for drug delivery. Measuring their size is one of the crucial parameters in their characterization, to ensure drug safety, stability, and effectiveness. Over the past two decades, Taylor Dispersion Analysis has emerged as an important sizing method. Its scope of application is perfectly suited to the sizes of these therapeutics. By design, it can be coupled with a wide range of detectors, and extensive research has been conducted in this field. In this review, we will present an overview of the studies conducted, and discuss how the application drives the choice of one detector or another (size measurement, aggregation studies, interaction studies, and other analyses, performed in both simple biological buffers and in more complex media, particularly serum) and makes Taylor Dispersion Analysis a highly versatile tool.
SN - 1424-8247
ER -