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Peer-reviewedCC BYACG case reports journal

Case of Appendiceal Goblet Cell Adenocarcinoma With Gastric Metastasis.

  • A Gautam1
  • M Jafferjee1
  • K Nimmagadda1
  • M Simien1,2
  • M Cimo1
  1. 1Baylor Scott & White All Saints Medical Center, Fort Worth, TX.
  2. 2Baylor Scott and White Digestive Diseases, Fort Worth, TX.
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Abstract

Goblet cell adenocarcinoma (GCA) is a rare appendiceal neoplasm that typically metastasizes to the peritoneum and pelvic organs, with no reported gastric involvement. We report a 72-year-old man with multiple comorbidities presenting with recurrent small bowel obstruction. Imaging revealed a cecal and a gastric mass; colonoscopy confirmed poorly differentiated right-sided adenocarcinoma. Surgical resection with intraoperative biopsies identified high-grade appendiceal GCA infiltrating the cecum, mesentery, and gastric wall. Immunohistochemical staining showed cytokeratin 7 negativity and cytokeratin 20 positivity, suggesting an appendiceal origin. Endoscopic ultrasound-guided fine-needle aspiration of the gastric lesion confirmed gastric metastasis, demonstrating identical morphology and immunoprofile, thus expanding the metastatic spectrum of GCA.

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Cite

BibTeXRIS
BibTeX
@article{gautam2026case,
  title = {{Case of Appendiceal Goblet Cell Adenocarcinoma With Gastric Metastasis.}},
  author = {A Gautam and M Jafferjee and K Nimmagadda and M Simien and M Cimo},
  journal = {ACG case reports journal},
  year = {2026},
  month = oct,
  doi = {10.14309/crj.0000000000002347},
  url = {https://europepmc.org/article/MED/42910385},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Case of Appendiceal Goblet Cell Adenocarcinoma With Gastric Metastasis.
AU  - A Gautam
AU  - M Jafferjee
AU  - K Nimmagadda
AU  - M Simien
AU  - M Cimo
PY  - 2026
DA  - 2026/10/21
JO  - ACG case reports journal
DO  - 10.14309/crj.0000000000002347
UR  - https://europepmc.org/article/MED/42910385
AB  - Goblet cell adenocarcinoma (GCA) is a rare appendiceal neoplasm that typically metastasizes to the peritoneum and pelvic organs, with no reported gastric involvement. We report a 72-year-old man with multiple comorbidities presenting with recurrent small bowel obstruction. Imaging revealed a cecal and a gastric mass; colonoscopy confirmed poorly differentiated right-sided adenocarcinoma. Surgical resection with intraoperative biopsies identified high-grade appendiceal GCA infiltrating the cecum, mesentery, and gastric wall. Immunohistochemical staining showed cytokeratin 7 negativity and cytokeratin 20 positivity, suggesting an appendiceal origin. Endoscopic ultrasound-guided fine-needle aspiration of the gastric lesion confirmed gastric metastasis, demonstrating identical morphology and immunoprofile, thus expanding the metastatic spectrum of GCA.
SN  - 2326-3253
ER  -