PreprintCC BYbioRxiv
Nucleic acid 3D structure search and alignment with GTalign
- 1Institute of Biotechnology, Vilnius University
Abstract
Structural comparison of nucleic acids, particularly RNA, is critical for understanding evolutionary and functional relationships beyond sequence similarity, yet efficient tools for large-scale 3D structure search and alignment remain scarce. We extend GTalign to support nucleic acid structures, enabling unified, high-performance alignment across macromolecules. Benchmarking on diverse nucleic acid datasets demonstrates improved alignment accuracy and substantially lower runtimes compared to existing methods. GTalign thus provides a scalable solution for nucleic acid structure comparison and database search. Availability and Implementation: https://github.com/minmarg/gtalign_alpha
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BibTeX
@misc{margelevicius2026nucleic,
title = {{Nucleic acid 3D structure search and alignment with GTalign}},
author = {M. Margelevicius and S. Rana},
howpublished = {bioRxiv},
year = {2026},
month = jun,
doi = {10.64898/2026.06.01.729228},
url = {https://www.biorxiv.org/content/10.64898/2026.06.01.729228v2},
note = {CC BY},
}
RIS
TY - UNPB
TI - Nucleic acid 3D structure search and alignment with GTalign
AU - M. Margelevicius
AU - S. Rana
PY - 2026
DA - 2026/06/01
PB - bioRxiv
DO - 10.64898/2026.06.01.729228
UR - https://www.biorxiv.org/content/10.64898/2026.06.01.729228v2
AB - Structural comparison of nucleic acids, particularly RNA, is critical for understanding evolutionary and functional relationships beyond sequence similarity, yet efficient tools for large-scale 3D structure search and alignment remain scarce. We extend GTalign to support nucleic acid structures, enabling unified, high-performance alignment across macromolecules. Benchmarking on diverse nucleic acid datasets demonstrates improved alignment accuracy and substantially lower runtimes compared to existing methods. GTalign thus provides a scalable solution for nucleic acid structure comparison and database search. Availability and Implementation: https://github.com/minmarg/gtalign_alpha
ER -