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Peer-reviewedCC BYGeoHealth

Asthma Exacerbations Following Wildfire Smoke PM2.5 Exposure Among U.S. Adults.

  • Yanhong Huang1,2,3
  • Li Luo4,5
  • Shuguang Leng4,5,6
  • Su Zhang3,7
  • Roberta P Lavin8
  • Michaela Buenemann9
  • Yan Lin10,11
  • Matthew Campen12
  • Xi Gong2,13
13 affiliations
  1. 1Department of Veterinary Physiology and Pharmacology Texas A&M University College Station TX USA.
  2. 2Department of Biobehavioral Health The Pennsylvania State University University Park PA USA.
  3. 3Department of Geography & Environmental Studies University of New Mexico Albuquerque NM USA.
  4. 4Department of Internal Medicine University of New Mexico Albuquerque NM USA.
  5. 5University of New Mexico Comprehensive Cancer Center Albuquerque NM USA.
  6. 6Lung Cancer Program Lovelace Biomedical Research Institute Albuquerque NM USA.
  7. 7Earth Data Analysis Center (EDAC) University of New Mexico Albuquerque NM USA.
  8. 8Center for Health Equity and Preparedness College of Nursing University of New Mexico Albuquerque NM USA.
  9. 9Department of Geography and Environmental Studies New Mexico State University Las Cruces NM USA.
  10. 10Department of Geography The Pennsylvania State University University Park PA USA.
  11. 11Social Science Research Institute (SSRI) The Pennsylvania State University University Park PA USA.
  12. 12Department of Pharmaceutical Sciences College of Pharmacy University of New Mexico Albuquerque NM USA.
  13. 13Institute for Computational and Data Sciences (ICDS) The Pennsylvania State University University Park PA USA.
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Abstract

Asthma exacerbation can be triggered by various forms of air pollution, including PM2.5 from wildfire smoke. This study aims to investigate the association between wildfire smoke PM2.5 exposure and asthma exacerbations in adults during the warm months (April-August) between 2006 and 2019. Using a case-crossover design, we analyzed 18,935 asthma exacerbation events and four matched control periods per event from the National Institutes of Health (NIH) All of Us research program. We used the conditional logistic regression to estimate the association (odds ratios [ORs]) between wildfire smoke PM2.5 exposure and asthma exacerbation, considering lag periods of 0-7 days and adjusting for temperature, precipitation, and humidity. Significant positive associations were observed across all lag periods, with adjusted ORs ranging from 1.27 (95% CI: 1.22-1.33) to 1.38 (95% CI: 1.32-1.44). Stratified analyses showed higher odds of asthma exacerbation among older adults, non-Hispanic Whites, midwestern residents, and those exposed in May. These findings highlight the potential contribution of wildfire smoke PM2.5 to asthma exacerbations in adults and the importance of targeted public health strategies to reduce exposure during wildfire events.

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Cite

BibTeXRIS
BibTeX
@article{huang2026asthma,
  title = {{Asthma Exacerbations Following Wildfire Smoke PM2.5 Exposure Among U.S. Adults.}},
  author = {Yanhong Huang and Li Luo and Shuguang Leng and Su Zhang and Roberta P Lavin and Michaela Buenemann and Yan Lin and Matthew Campen and Xi Gong},
  journal = {GeoHealth},
  year = {2026},
  month = nov,
  doi = {10.1029/2026gh001972},
  url = {https://europepmc.org/article/MED/42999790},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Asthma Exacerbations Following Wildfire Smoke PM2.5 Exposure Among U.S. Adults.
AU  - Yanhong Huang
AU  - Li Luo
AU  - Shuguang Leng
AU  - Su Zhang
AU  - Roberta P Lavin
AU  - Michaela Buenemann
AU  - Yan Lin
AU  - Matthew Campen
AU  - Xi Gong
PY  - 2026
DA  - 2026/11/07
JO  - GeoHealth
DO  - 10.1029/2026gh001972
UR  - https://europepmc.org/article/MED/42999790
AB  - Asthma exacerbation can be triggered by various forms of air pollution, including PM2.5 from wildfire smoke. This study aims to investigate the association between wildfire smoke PM2.5 exposure and asthma exacerbations in adults during the warm months (April-August) between 2006 and 2019. Using a case-crossover design, we analyzed 18,935 asthma exacerbation events and four matched control periods per event from the National Institutes of Health (NIH) All of Us research program. We used the conditional logistic regression to estimate the association (odds ratios [ORs]) between wildfire smoke PM2.5 exposure and asthma exacerbation, considering lag periods of 0-7 days and adjusting for temperature, precipitation, and humidity. Significant positive associations were observed across all lag periods, with adjusted ORs ranging from 1.27 (95% CI: 1.22-1.33) to 1.38 (95% CI: 1.32-1.44). Stratified analyses showed higher odds of asthma exacerbation among older adults, non-Hispanic Whites, midwestern residents, and those exposed in May. These findings highlight the potential contribution of wildfire smoke PM2.5 to asthma exacerbations in adults and the importance of targeted public health strategies to reduce exposure during wildfire events.
SN  - 2471-1403
ER  -