Microneedles for Chronic Refractory Wounds: A Review of Dynamic Regulation Strategies and Therapeutic Applications.
- 1State Key Laboratory of Trauma and Chemical Poisoning, Institute of Rocket Force Medicine, Third Military Medical University (Army Medical University), Gaotanyan Road Street, Shapingba District, Chongqing 400038, China.
Abstract
Chronic refractory wounds (CRWs), characterized by delayed healing due to disrupted phases of hemostasis, inflammation, proliferation, and remodeling, pose significant clinical challenges with diverse etiologies such as diabetic ulcers and radiation-induced ulcers. Traditional therapies like debridement and skin flap transplantation face limitations. Microneedle technology has emerged as a promising approach, enabling painless transdermal drug delivery to the dermis while enhancing bioavailability and enabling microenvironment-responsive interventions. In this context, this review highlights advancements in microneedle design, emphasizing material selection and structural innovations tailored for CRW management, and systematically elucidates the mechanisms of action and applications of microneedles for phased regulation of CRW healing in response to the pathologic characteristics of wounds-hemostatic, inflammation regulation, angiogenesis and remodeling stage-in terms of prevention, intervention, and wound monitoring, thereby providing significant reference value for the design and clinical application of microneedles in chronic refractory wounds.
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BibTeX
@article{liu2026microneedles,
title = {{Microneedles for Chronic Refractory Wounds: A Review of Dynamic Regulation Strategies and Therapeutic Applications.}},
author = {Quanying Liu and Yang Xu and Wenfeng Li and Chunmeng Shi},
journal = {International journal of molecular sciences},
year = {2026},
month = sep,
doi = {10.3390/ijms27198520},
url = {https://europepmc.org/article/MED/42883766},
note = {CC BY},
}
RIS
TY - JOUR
TI - Microneedles for Chronic Refractory Wounds: A Review of Dynamic Regulation Strategies and Therapeutic Applications.
AU - Quanying Liu
AU - Yang Xu
AU - Wenfeng Li
AU - Chunmeng Shi
PY - 2026
DA - 2026/09/24
JO - International journal of molecular sciences
DO - 10.3390/ijms27198520
UR - https://europepmc.org/article/MED/42883766
AB - Chronic refractory wounds (CRWs), characterized by delayed healing due to disrupted phases of hemostasis, inflammation, proliferation, and remodeling, pose significant clinical challenges with diverse etiologies such as diabetic ulcers and radiation-induced ulcers. Traditional therapies like debridement and skin flap transplantation face limitations. Microneedle technology has emerged as a promising approach, enabling painless transdermal drug delivery to the dermis while enhancing bioavailability and enabling microenvironment-responsive interventions. In this context, this review highlights advancements in microneedle design, emphasizing material selection and structural innovations tailored for CRW management, and systematically elucidates the mechanisms of action and applications of microneedles for phased regulation of CRW healing in response to the pathologic characteristics of wounds-hemostatic, inflammation regulation, angiogenesis and remodeling stage-in terms of prevention, intervention, and wound monitoring, thereby providing significant reference value for the design and clinical application of microneedles in chronic refractory wounds.
SN - 1422-0067
ER -