Impact of portal hypertension on clinical outcomes in critically Ill adult patients: A retrospective study: Outcomes in critically Ill patients with portal hypertension.
- 1Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
- 2Zhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang, Zhejiang Hospital, Hangzhou China.
Abstract
Liver dysfunction is a common complication in critically ill patients, and portal hypertension (PHT) represents a severe hepatic pathological condition closely associated with adverse patient outcomes. This study aims to investigate the impact of PHT on clinical outcomes in critically ill adult patients. Data were extracted from the Medical Information Market for Intensive Care IV database. All critically ill patients admitted to the hospital were included in this study. Logistic regression analysis was used to assess the correlation between PHT and hospital mortality, length of stay in the intensive care unit (LOS-ICU), and length of stay in hospital in critically ill patients, and multiple collinearity checks were performed. Propensity score matching was used to minimize group differences, and subgroup analyses were conducted. A total of 46,804 adult critically ill patients were included in this study. The hospital mortality rate for critically ill patients with PHT was 19%, significantly higher than the 8.8% mortality rate for patients without PHT (P < .05). Critically ill patients with PHT also had longer LOS-ICU and length of stay in hospital and higher total bilirubin levels (P < .05). Furthermore, multivariate logistic regression analysis showed that PHT was significantly associated with hospital mortality (OR: 2.716, 95% CI: 2.330-3.158, P < .001). After propensity score matching, the baseline differences between the 2 groups were significantly reduced, and the results showed that critically ill patients with PHT had worse clinical outcomes. However, the LOS-ICU was not significantly different after matching. PHT is a significant predictor of poor prognosis in critically ill adult patients, necessitating enhanced clinical monitoring and management to improve their clinical outcomes.
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BibTeX
@article{shen2026impact,
title = {{Impact of portal hypertension on clinical outcomes in critically Ill adult patients: A retrospective study: Outcomes in critically Ill patients with portal hypertension.}},
author = {Xing-Kai Shen and Jia-Lu Chen and Yi Ding and Shan-Shan Huang and Zhou-Xin Yang},
journal = {Medicine},
year = {2026},
month = oct,
doi = {10.1097/md.0000000000051129},
url = {https://europepmc.org/article/MED/42888530},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Impact of portal hypertension on clinical outcomes in critically Ill adult patients: A retrospective study: Outcomes in critically Ill patients with portal hypertension.
AU - Xing-Kai Shen
AU - Jia-Lu Chen
AU - Yi Ding
AU - Shan-Shan Huang
AU - Zhou-Xin Yang
PY - 2026
DA - 2026/10/01
JO - Medicine
DO - 10.1097/md.0000000000051129
UR - https://europepmc.org/article/MED/42888530
AB - Liver dysfunction is a common complication in critically ill patients, and portal hypertension (PHT) represents a severe hepatic pathological condition closely associated with adverse patient outcomes. This study aims to investigate the impact of PHT on clinical outcomes in critically ill adult patients. Data were extracted from the Medical Information Market for Intensive Care IV database. All critically ill patients admitted to the hospital were included in this study. Logistic regression analysis was used to assess the correlation between PHT and hospital mortality, length of stay in the intensive care unit (LOS-ICU), and length of stay in hospital in critically ill patients, and multiple collinearity checks were performed. Propensity score matching was used to minimize group differences, and subgroup analyses were conducted. A total of 46,804 adult critically ill patients were included in this study. The hospital mortality rate for critically ill patients with PHT was 19%, significantly higher than the 8.8% mortality rate for patients without PHT (P < .05). Critically ill patients with PHT also had longer LOS-ICU and length of stay in hospital and higher total bilirubin levels (P < .05). Furthermore, multivariate logistic regression analysis showed that PHT was significantly associated with hospital mortality (OR: 2.716, 95% CI: 2.330-3.158, P < .001). After propensity score matching, the baseline differences between the 2 groups were significantly reduced, and the results showed that critically ill patients with PHT had worse clinical outcomes. However, the LOS-ICU was not significantly different after matching. PHT is a significant predictor of poor prognosis in critically ill adult patients, necessitating enhanced clinical monitoring and management to improve their clinical outcomes.
SN - 0304-5412
SN - 1536-5964
ER -