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Peer-reviewedCC BY-NC-NDMedical mycology case reports

Blood culture-positive Aspergillus niger native aortic valve endocarditis presenting as acute lower limb ischemia: a case report.

  • Silvia Taurian1,2
  • Matthias Neuböck1,2
  • Mohsen Alavian3
  • Helmut Salzer1,2,4
4 affiliations
  1. 1Medical Faculty, Johannes Kepler University, Linz, Austria.
  2. 2Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine 4 - Pneumology, Kepler University Hospital, Krankenhausstrasse 9, Linz, 4021, Austria.
  3. 3Department of Cardio-Thoracic and Vascular Surgery, Johannes Kepler University Hospital Linz, Austria.
  4. 4Ignaz Semmelweis Institut, Interuniversity Institute for Infection Research, Vienna, Austria.
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Abstract

Aspergillus endocarditis is a rare, life-threatening infection in which blood cultures are almost invariably negative. We report an exceptional case of blood culture-positive native aortic valve endocarditis caused by Aspergillus niger, presenting with acute limb ischemia. Concordant isolation of A. niger from peripheral blood cultures, embolic material, and resected valve tissue provided robust microbiological confirmation. Early surgical valve replacement combined with susceptibility-guided antifungal therapy enabled prompt targeted management and a favorable clinical outcome.

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Cite

BibTeXRIS
BibTeX
@article{taurian2026blood,
  title = {{Blood culture-positive Aspergillus niger native aortic valve endocarditis presenting as acute lower limb ischemia: a case report.}},
  author = {Silvia Taurian and Matthias Neuböck and Mohsen Alavian and Helmut Salzer},
  journal = {Medical mycology case reports},
  year = {2026},
  month = oct,
  doi = {10.1016/j.mmcr.2026.100828},
  url = {https://europepmc.org/article/MED/42899160},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Blood culture-positive Aspergillus niger native aortic valve endocarditis presenting as acute lower limb ischemia: a case report.
AU  - Silvia Taurian
AU  - Matthias Neuböck
AU  - Mohsen Alavian
AU  - Helmut Salzer
PY  - 2026
DA  - 2026/10/09
JO  - Medical mycology case reports
DO  - 10.1016/j.mmcr.2026.100828
UR  - https://europepmc.org/article/MED/42899160
AB  - Aspergillus endocarditis is a rare, life-threatening infection in which blood cultures are almost invariably negative. We report an exceptional case of blood culture-positive native aortic valve endocarditis caused by Aspergillus niger, presenting with acute limb ischemia. Concordant isolation of A. niger from peripheral blood cultures, embolic material, and resected valve tissue provided robust microbiological confirmation. Early surgical valve replacement combined with susceptibility-guided antifungal therapy enabled prompt targeted management and a favorable clinical outcome.
SN  - 2211-7539
ER  -