Infective Endocarditis Presenting with Rapidly Progressive Cerebral Microbleeds and Multiple Intracerebral…

Abstract

Infective endocarditis (IE) is a serious condition that can lead to neurological complications, including hemorrhagic stroke. A 65-year-old man who had undergone mechanical mitral valve replacement at 63 years of age and had been on oral anticoagulant therapy developed multiple intracerebral hemorrhages (ICHs) and cerebral microbleeds (CMBs) within a short period. The patient was diagnosed with IE caused by Streptococcus mitis/oralis. He recovered with antibiotic treatment alone, resulting in a favorable outcome for the patient. This case emphasizes the importance of considering IE in the differential diagnosis for multiple cerebral hemorrhages and the association between anticoagulant therapy, multiple ICHs, and CMBs in IE.

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BibTeX

@article{sekiguchi2026infective,
  title = {{Infective Endocarditis Presenting with Rapidly Progressive Cerebral Microbleeds and Multiple Intracerebral Hemorrhages: A Case Report}},
  author = {Kazumasa Sekiguchi and Jun Sawada and Kosuke Matsuzono and Yusuke Ishiyama and Yuhei Anan and Reiji Koide and Ryota Tanaka and Shigeru Fujimoto},
  journal = {Internal Medicine},
  year = {2026},
  month = jul,
  doi = {10.2169/internalmedicine.7355-26},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7355-26/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Infective Endocarditis Presenting with Rapidly Progressive Cerebral Microbleeds and Multiple Intracerebral Hemorrhages: A Case Report
AU  - Kazumasa Sekiguchi
AU  - Jun Sawada
AU  - Kosuke Matsuzono
AU  - Yusuke Ishiyama
AU  - Yuhei Anan
AU  - Reiji Koide
AU  - Ryota Tanaka
AU  - Shigeru Fujimoto
PY  - 2026
DA  - 2026/07/18
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.7355-26
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7355-26/_article
AB  - Infective endocarditis (IE) is a serious condition that can lead to neurological complications, including hemorrhagic stroke. A 65-year-old man who had undergone mechanical mitral valve replacement at 63 years of age and had been on oral anticoagulant therapy developed multiple intracerebral hemorrhages (ICHs) and cerebral microbleeds (CMBs) within a short period. The patient was diagnosed with IE caused by Streptococcus mitis/oralis. He recovered with antibiotic treatment alone, resulting in a favorable outcome for the patient. This case emphasizes the importance of considering IE in the differential diagnosis for multiple cerebral hemorrhages and the association between anticoagulant therapy, multiple ICHs, and CMBs in IE.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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