Physicochemical and Release Characteristics of Andrographolide Liquisolid Systems Fabricated Based on Microcrystalline Cellulose, Magnesium Aluminometasilicate, and Their Blends
- 1Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
- 2Center for Research and Development of Herbal Health Products, Khon Kaen University, Khon Kaen 40002, Thailand
- 3College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand
Abstract
This study aimed to investigate physicochemical properties and release characteristics of andrographolide liquisolid systems developed using microcrystalline cellulose (MCC), magnesium aluminometasilicate (NEU), and their combinations (MCC:NEU) as carriers. Polyoxyl 15 hydroxystearate combined with N-methyl-2-pyrrolidone as a non-volatile liquid vehicle facilitated AG solubility, leading to the transformation into non-crystalline AG in the liquisolid powder, as demonstrated via PXRD. NEU-based liquisolid powder exhibited a greater liquid-loading factor than that of MCC (0.925 vs. 0.202). Liquid-loading factor of MCC:NEU exhibited a notable improvement, resulting in an increase in AG loading from 1.63% to 4.20% as the NEU content increased from 0% to 75%. MCC:NEU-based liquisolid powders exhibited greater AG release and tabletability than MCC-based powders. Five prepared AG liquisolid tablets based on liquisolid powder, sodium starch glycolate (4%), and magnesium stearate (1%) had acceptable tablet properties and AG content uniformity. MCC-based liquisolid tablets showed a modest improvement in AG release with a release efficiency of 44.6 ± 2.5%, while NEU-based tablets had a release efficiency of 8.7 ± 0.7%. MCC:NEU-based AG liquisolid tablets exhibited increased disintegration time and thus significantly suppressed AG release. This suggests that a justification for the design of MCC:NEU liquisolid tablets with prompt disintegration is essential for achieving superior AG release.
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BibTeX
@article{jaipakdee2026physicochemical,
title = {{Physicochemical and Release Characteristics of Andrographolide Liquisolid Systems Fabricated Based on Microcrystalline Cellulose, Magnesium Aluminometasilicate, and Their Blends}},
author = {Napaphak Jaipakdee and Peera Tabboon and Pinpair Ekkanjanakorn and Kattiya Sonchiangkham and Thaned Pongjanyakul and Ekapol Limpongsa},
journal = {Polymers},
year = {2026},
month = oct,
doi = {10.3390/polym18212667},
url = {https://www.mdpi.com/2073-4360/18/21/2667},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Physicochemical and Release Characteristics of Andrographolide Liquisolid Systems Fabricated Based on Microcrystalline Cellulose, Magnesium Aluminometasilicate, and Their Blends
AU - Napaphak Jaipakdee
AU - Peera Tabboon
AU - Pinpair Ekkanjanakorn
AU - Kattiya Sonchiangkham
AU - Thaned Pongjanyakul
AU - Ekapol Limpongsa
PY - 2026
DA - 2026/10/28
JO - Polymers
DO - 10.3390/polym18212667
UR - https://www.mdpi.com/2073-4360/18/21/2667
AB - This study aimed to investigate physicochemical properties and release characteristics of andrographolide liquisolid systems developed using microcrystalline cellulose (MCC), magnesium aluminometasilicate (NEU), and their combinations (MCC:NEU) as carriers. Polyoxyl 15 hydroxystearate combined with N-methyl-2-pyrrolidone as a non-volatile liquid vehicle facilitated AG solubility, leading to the transformation into non-crystalline AG in the liquisolid powder, as demonstrated via PXRD. NEU-based liquisolid powder exhibited a greater liquid-loading factor than that of MCC (0.925 vs. 0.202). Liquid-loading factor of MCC:NEU exhibited a notable improvement, resulting in an increase in AG loading from 1.63% to 4.20% as the NEU content increased from 0% to 75%. MCC:NEU-based liquisolid powders exhibited greater AG release and tabletability than MCC-based powders. Five prepared AG liquisolid tablets based on liquisolid powder, sodium starch glycolate (4%), and magnesium stearate (1%) had acceptable tablet properties and AG content uniformity. MCC-based liquisolid tablets showed a modest improvement in AG release with a release efficiency of 44.6 ± 2.5%, while NEU-based tablets had a release efficiency of 8.7 ± 0.7%. MCC:NEU-based AG liquisolid tablets exhibited increased disintegration time and thus significantly suppressed AG release. This suggests that a justification for the design of MCC:NEU liquisolid tablets with prompt disintegration is essential for achieving superior AG release.
SN - 2073-4360
ER -