Physiological and Transcriptional Responses of the Blood Clam Anadara kagoshimensis (Tokunaga, 1906) During Cadmium Exposure.
5 affiliations
- 1Tianjin Key Laboratory of Aquatic Ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin 300384, China.
- 2Key Laboratory of Smart Breeding (Co-Construction by Ministry and Province, Ministry of Agriculture and Rural Affairs), Tianjin Agricultural University, Tianjin 300384, China.
- 3College of Fisheries and Economy, Tangshan Maritime Institute, Tangshan 063200, China.
- 4Agricultural and Rural Development Service Center of Binhai New Area, Tianjin 300452, China.
- 5Tianjin Fisheries Research Institute, Tianjin 300221, China.
Abstract
Cadmium (Cd) exposure can affect metal handling, metabolism and tissue condition in bivalves on different timescales. We examined these responses in the blood clam Anadara kagoshimensis (Tokunaga, 1906) exposed to a nominal Cd concentration of 100 μg/L. Respiration, tissue Cd, redox biomarkers and histology were assessed over 480 h, alongside hepatopancreas RNA profiles at 0 h, 24 h and 21 d. Oxygen consumption reached its lowest exposed mean at 96 h. At 480 h, Cd concentrations were 44.23 ± 8.99 μg/g dry weight in the hepatopancreas and 31.75 ± 1.81 μg/g in the gill. SOD and CAT activities followed tissue-specific trajectories, GSH content declined, and MDA showed non-monotonic changes. Histological observations included epithelial detachment and disruption of digestive tubule structure. Descriptive expression comparisons identified metal handling, redox, cell-death and immune-related candidates, with more twofold expression differences at 21 d than at 24 h. qRT-PCR examined ten selected targets using three tank-derived RNA samples per time. Together, the physiological measurements, tissue observations and exploratory expression profiles describe a tissue- and time-dependent response to Cd exposure and identify candidates for further functional study.
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BibTeX
@article{ren2026physiological,
title = {{Physiological and Transcriptional Responses of the Blood Clam Anadara kagoshimensis (Tokunaga, 1906) During Cadmium Exposure.}},
author = {Yuxin Ren and Fei Li and Xindong Xing and Haocheng Li and Hong Yu and Huiru Liu and Zhixiong Zhou and Xiaoyu Wang and Jian Liang and Chunxiu Chen and Yongjun Guo and Shuang Liang},
journal = {Toxics},
year = {2026},
month = sep,
doi = {10.3390/toxics14100883},
url = {https://europepmc.org/article/MED/42931670},
note = {CC BY},
}
RIS
TY - JOUR
TI - Physiological and Transcriptional Responses of the Blood Clam Anadara kagoshimensis (Tokunaga, 1906) During Cadmium Exposure.
AU - Yuxin Ren
AU - Fei Li
AU - Xindong Xing
AU - Haocheng Li
AU - Hong Yu
AU - Huiru Liu
AU - Zhixiong Zhou
AU - Xiaoyu Wang
AU - Jian Liang
AU - Chunxiu Chen
AU - Yongjun Guo
AU - Shuang Liang
PY - 2026
DA - 2026/09/30
JO - Toxics
DO - 10.3390/toxics14100883
UR - https://europepmc.org/article/MED/42931670
AB - Cadmium (Cd) exposure can affect metal handling, metabolism and tissue condition in bivalves on different timescales. We examined these responses in the blood clam Anadara kagoshimensis (Tokunaga, 1906) exposed to a nominal Cd concentration of 100 μg/L. Respiration, tissue Cd, redox biomarkers and histology were assessed over 480 h, alongside hepatopancreas RNA profiles at 0 h, 24 h and 21 d. Oxygen consumption reached its lowest exposed mean at 96 h. At 480 h, Cd concentrations were 44.23 ± 8.99 μg/g dry weight in the hepatopancreas and 31.75 ± 1.81 μg/g in the gill. SOD and CAT activities followed tissue-specific trajectories, GSH content declined, and MDA showed non-monotonic changes. Histological observations included epithelial detachment and disruption of digestive tubule structure. Descriptive expression comparisons identified metal handling, redox, cell-death and immune-related candidates, with more twofold expression differences at 21 d than at 24 h. qRT-PCR examined ten selected targets using three tank-derived RNA samples per time. Together, the physiological measurements, tissue observations and exploratory expression profiles describe a tissue- and time-dependent response to Cd exposure and identify candidates for further functional study.
SN - 2305-6304
ER -