Sugar Depletion in Korean Pine Infected with Cronartium ribicola, Alongside Metabolic Reprogramming by the T6P–Tre Signaling Module
- 1Key Laboratory of Alien Forest Pest Detection and Control-Heilongjiang Province, College of Forestry, Northeast Forestry University, Harbin 150040, China
- 2Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, Northeast Forestry University, Harbin 150040, China
Abstract
In diseased Korean pine trees (Pinus koraiensis), Cronartium ribicola develops aecia only in the bole, where sugar is initially sufficient. However, the molecular mechanisms underlying sugar depletion in diseased Korean pine trees remain unelucidated, hindering sugar-targeted control strategies. Focusing on host responses, this study integrated metabolomics, transcriptomics, and targeted glycomics based on spatial partitioning to investigate sugar metabolic reprogramming in the bole of diseased pines. Multi-omics revealed severe sugar depletion in the blister area, which was significantly correlated with relative C. ribicola DNA level. However, the transcription of sugar synthesis genes was upregulated, while sugar degradation genes were downregulated, indicating decoupling between sugar metabolism and transcription. Concurrently, T6P–Tre-centered reprogramming was identified: Pktppd and Pktpp4, encoding enzymes that convert T6P into Tre, were downregulated, leading to elevated T6P and reduced Tre levels. This T6P–Tre shift likely acts as a signal to activate genes related to sugar accumulation in response to sugar depletion, thereby explaining the observed transcriptional-metabolic decoupling. Targeting the T6P–Tre module to modulate host sugar allocation and restrict sugar availability to the pathogen may offer a novel strategy for the targeted control of Korean pine blister rust (KPBR).
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BibTeX
@article{wang2026sugar,
title = {{Sugar Depletion in Korean Pine Infected with Cronartium ribicola, Alongside Metabolic Reprogramming by the T6P–Tre Signaling Module}},
author = {Jianan Wang and Bing Wang and Qi Yu and Ruizhi Zhang and Bin Tan and Zifei Feng and Feng Wang and Danlei Li},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27219441},
url = {https://www.mdpi.com/1422-0067/27/21/9441},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Sugar Depletion in Korean Pine Infected with Cronartium ribicola, Alongside Metabolic Reprogramming by the T6P–Tre Signaling Module
AU - Jianan Wang
AU - Bing Wang
AU - Qi Yu
AU - Ruizhi Zhang
AU - Bin Tan
AU - Zifei Feng
AU - Feng Wang
AU - Danlei Li
PY - 2026
DA - 2026/10/23
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27219441
UR - https://www.mdpi.com/1422-0067/27/21/9441
AB - In diseased Korean pine trees (Pinus koraiensis), Cronartium ribicola develops aecia only in the bole, where sugar is initially sufficient. However, the molecular mechanisms underlying sugar depletion in diseased Korean pine trees remain unelucidated, hindering sugar-targeted control strategies. Focusing on host responses, this study integrated metabolomics, transcriptomics, and targeted glycomics based on spatial partitioning to investigate sugar metabolic reprogramming in the bole of diseased pines. Multi-omics revealed severe sugar depletion in the blister area, which was significantly correlated with relative C. ribicola DNA level. However, the transcription of sugar synthesis genes was upregulated, while sugar degradation genes were downregulated, indicating decoupling between sugar metabolism and transcription. Concurrently, T6P–Tre-centered reprogramming was identified: Pktppd and Pktpp4, encoding enzymes that convert T6P into Tre, were downregulated, leading to elevated T6P and reduced Tre levels. This T6P–Tre shift likely acts as a signal to activate genes related to sugar accumulation in response to sugar depletion, thereby explaining the observed transcriptional-metabolic decoupling. Targeting the T6P–Tre module to modulate host sugar allocation and restrict sugar availability to the pathogen may offer a novel strategy for the targeted control of Korean pine blister rust (KPBR).
SN - 1422-0067
ER -