Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 9 min ago
Peer-reviewedCC BY 4.0Nutrients

Effects of a Targeted Nutritional Intervention on Auditory–Visual Event-Related Potentials in South-Indian Infants: An Exploratory Analysis of a Cluster Randomized Trial

  • Akshata A. Kamath1,2
  • Chaitra A. Kilpady1,2
  • Prashansa Tripathi3
  • Aswathi Saji1,4
  • Sumit Sharma3
  • Rahul Venugopal5
  • Arun Sasidharan5
  • Nirupama Shivakumar2
  • Anura V. Kurpad6
6 affiliations
  1. 1Centre for Doctoral Studies, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
  2. 2Division of Nutrition, St. John’s Research Institute, St. John’s National Academy of Health Sciences (A Unit of CBCI Society for Medical Education), Bangalore 560034, Karnataka, India
  3. 3Axxonet System Technologies, Bangalore 560029, Karnataka, India
  4. 4Division of Epidemiology and Biostatistics, St. John’s Research Institute, St. John’s National Academy of Health Sciences (A Unit of CBCI Society for Medical Education), Bangalore 560034, Karnataka, India
  5. 5Centre for Consciousness Studies, Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bangalore 560029, Karnataka, India
  6. 6Department of Physiology, St. John’s Medical College, St. John’s National Academy of Health Sciences (A Unit of CBCI Society for Medical Education), Bangalore 560034, Karnataka, India
Open at sourceDOICite

Abstract

Background/Objectives: Inadequate macronutrient intake may affect neurodevelopment in early infancy. In India, government-supplied take-home rations (THRs) attempt to meet this gap but lack adequate fat and protein. This study evaluated the impact of a 3-month macronutrient modified-THR intervention on infant neurodevelopment using event-related potentials (ERPs). Methods: A two-group cluster randomized controlled trial (village clusters = 12/group; N = 67/group) enrolled healthy breastfed infants (6–9 months) in Karnataka, India. The intervention group received a milk–legume-based THR providing ~200 kcal/day (ML-THR, estimated protein:energy (PE) and fat:energy (FE) ratios: 12% and 45%) with the standard government THR (SG-THR, estimated PE and FE ratios: 7% and 4%), while controls received SG-THRs only. All mothers received education on infant and young child feeding practices, water sanitation and hygiene. Auditory, visual and attention processing ERPs were measured using a short, culturally adapted, infant-friendly paradigm. Linear mixed models evaluated intervention effects over time. Results: The intervention was associated with region-specific visual ERP changes: increased fractional latencies in anterior regions for face, nonface (500–750 ms); decreased fractional latencies in the central region for frequent (10–250 ms) and face (500–750 ms) and in the posterior region for frequent–rare difference (250–500 ms). The intervention group also demonstrated a reduced area under the curve for nonface stimuli (250–500 ms). No significant auditory or visual hemifield effects were observed. None of the observed effects remained significant after false discovery rate (FDR) correction. Conclusions: The findings are exploratory and suggest the need to examine the effects of improved protein quality and fat content in THRs on visual–cortical processing in larger samples.

Related

  1. mHealth-based lifestyle intervention for hypertension in community-dwelling adults: a cluster-randomized controlled trial with exploratory multi-omics analyses
    Bin Yu, Haojiang Zuo, Xue Yang +5
    BMC MedicinePeer-reviewedCC BY 4.0General medicineCrossref
  2. Targeted uterine artery infusion of bone marrow-derived mesenchymal stem cells for severe intrauterine adhesions: a randomized controlled trial with exploratory translational analyses
    Yajie Chang, Qi Guo, Zhi Zeng +9
    Stem Cell Research & TherapyPeer-reviewedCC BY-NC-ND 4.0Full textObstetrics, gynaecology & paediatricsPMC
  3. Lipedema in a male patient: familial evidence and clinical response to nutritional intervention – case report Lipedema em paciente masculino: evidência familiar e resposta clínica à intervenção nutricional – relato de caso
    Michelle Kaefer, Bruna Candia Piccoli, Sabrina Fontana de Andrade +5
    Jornal vascular brasileiroPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Amyloid-Independent Elevation of Plasma phosphorylated tau-217 Tracks Neurodegenerative Risk in Tuberous Sclerosis Complex: Implications for mTOR-Targeted Intervention
    J. Baumel, M. Lutz, C. Ding +6
    medRxivPreprintAll rights reservedFull textNeurologymedRxiv
  5. Weight Loss and Long-Term Weight Trajectories After a Structured Nutritional and Behavioral Intervention: A Large Real-World Cohort Study
    Odile Fabre, Sébastien Bailly, Laurent Pantagis +5
    NutrientsPeer-reviewedCC BY 4.0Full textEpidemiology & public healthCrossrefEurope PMC

Cite

BibTeXRIS
BibTeX
@article{kamath2026effects,
  title = {{Effects of a Targeted Nutritional Intervention on Auditory–Visual Event-Related Potentials in South-Indian Infants: An Exploratory Analysis of a Cluster Randomized Trial}},
  author = {Akshata A. Kamath and Chaitra A. Kilpady and Prashansa Tripathi and Aswathi Saji and Sumit Sharma and Rahul Venugopal and Arun Sasidharan and Nirupama Shivakumar and Anura V. Kurpad},
  journal = {Nutrients},
  year = {2026},
  month = nov,
  doi = {10.3390/nu18213664},
  url = {https://www.mdpi.com/2072-6643/18/21/3664},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Effects of a Targeted Nutritional Intervention on Auditory–Visual Event-Related Potentials in South-Indian Infants: An Exploratory Analysis of a Cluster Randomized Trial
AU  - Akshata A. Kamath
AU  - Chaitra A. Kilpady
AU  - Prashansa Tripathi
AU  - Aswathi Saji
AU  - Sumit Sharma
AU  - Rahul Venugopal
AU  - Arun Sasidharan
AU  - Nirupama Shivakumar
AU  - Anura V. Kurpad
PY  - 2026
DA  - 2026/11/04
JO  - Nutrients
DO  - 10.3390/nu18213664
UR  - https://www.mdpi.com/2072-6643/18/21/3664
AB  - Background/Objectives: Inadequate macronutrient intake may affect neurodevelopment in early infancy. In India, government-supplied take-home rations (THRs) attempt to meet this gap but lack adequate fat and protein. This study evaluated the impact of a 3-month macronutrient modified-THR intervention on infant neurodevelopment using event-related potentials (ERPs). Methods: A two-group cluster randomized controlled trial (village clusters = 12/group; N = 67/group) enrolled healthy breastfed infants (6–9 months) in Karnataka, India. The intervention group received a milk–legume-based THR providing ~200 kcal/day (ML-THR, estimated protein:energy (PE) and fat:energy (FE) ratios: 12% and 45%) with the standard government THR (SG-THR, estimated PE and FE ratios: 7% and 4%), while controls received SG-THRs only. All mothers received education on infant and young child feeding practices, water sanitation and hygiene. Auditory, visual and attention processing ERPs were measured using a short, culturally adapted, infant-friendly paradigm. Linear mixed models evaluated intervention effects over time. Results: The intervention was associated with region-specific visual ERP changes: increased fractional latencies in anterior regions for face, nonface (500–750 ms); decreased fractional latencies in the central region for frequent (10–250 ms) and face (500–750 ms) and in the posterior region for frequent–rare difference (250–500 ms). The intervention group also demonstrated a reduced area under the curve for nonface stimuli (250–500 ms). No significant auditory or visual hemifield effects were observed. None of the observed effects remained significant after false discovery rate (FDR) correction. Conclusions: The findings are exploratory and suggest the need to examine the effects of improved protein quality and fat content in THRs on visual–cortical processing in larger samples.
SN  - 2072-6643
ER  -