Psychometric properties and longitudinal measurement invariance of the Functional Assessment of Cancer-Gynecologic Oncology Group-Neurotoxicity subscale in the Chinese colorectal cancer chemotherapy population.
5 affiliations
- 1School of Nursing, Nanjing Medical University, 101 Longmian Road, Nanjing, Jiangsu, 211166, China.
- 2Tianjin People's Hospital, Tianjin, China.
- 3The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
- 4The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
- 5School of Nursing, Nanjing Medical University, 101 Longmian Road, Nanjing, Jiangsu, 211166, China. [email protected].
Abstract
Background
Chemotherapy-induced peripheral neuropathy is a common and burdensome adverse effect of oxaliplatin-based chemotherapy in patients with colorectal cancer. The Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity subscale is used to assess neurotoxicity symptoms, but evidence regarding its psychometric performance and measurement invariance in Chinese patients remains limited. This study aimed to evaluate the psychometric properties and measurement invariance of the Chinese version of the FACT/GOG-Ntx13 in patients with colorectal cancer receiving oxaliplatin-based chemotherapy.Methods
A longitudinal quantitative survey was conducted among 534 Chinese patients with colorectal cancer. Data were collected one month and three months after the initiation of chemotherapy. Exploratory factor analysis, confirmatory factor analysis, measurement invariance testing, criterion validity analysis, and internal consistency reliability analysis were performed.Results
Exploratory factor analysis supported a one-factor structure, which was further confirmed by confirmatory factor analysis with acceptable model fit at both time points. The scale demonstrated good criterion-related validity through its positive correlation with the EORTC QLQ-CIPN20 and showed good internal consistency at both assessments. Measurement invariance across gender was supported at configural, metric, and scalar levels. Longitudinally, configural and metric invariance were supported, whereas scalar invariance was not.Conclusion
The Chinese version of the FACT/GOG-Ntx13 is a valid and reliable instrument for assessing oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer. However, changes in scores over time should be interpreted cautiously because longitudinal scalar invariance was not supported.
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BibTeX
@article{geng2026psychometric,
title = {{Psychometric properties and longitudinal measurement invariance of the Functional Assessment of Cancer-Gynecologic Oncology Group-Neurotoxicity subscale in the Chinese colorectal cancer chemotherapy population.}},
author = {Qingchun Geng and Yang Li and Hongwen Ma and Lina Xiong and Jiping Tan and Yanfei Jin},
journal = {Journal of patient-reported outcomes},
year = {2026},
month = jul,
doi = {10.1186/s41687-026-01167-1},
url = {https://europepmc.org/article/MED/42967975},
note = {CC BY},
}
RIS
TY - JOUR
TI - Psychometric properties and longitudinal measurement invariance of the Functional Assessment of Cancer-Gynecologic Oncology Group-Neurotoxicity subscale in the Chinese colorectal cancer chemotherapy population.
AU - Qingchun Geng
AU - Yang Li
AU - Hongwen Ma
AU - Lina Xiong
AU - Jiping Tan
AU - Yanfei Jin
PY - 2026
DA - 2026/07/31
JO - Journal of patient-reported outcomes
DO - 10.1186/s41687-026-01167-1
UR - https://europepmc.org/article/MED/42967975
AB - Background Chemotherapy-induced peripheral neuropathy is a common and burdensome adverse effect of oxaliplatin-based chemotherapy in patients with colorectal cancer. The Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity subscale is used to assess neurotoxicity symptoms, but evidence regarding its psychometric performance and measurement invariance in Chinese patients remains limited. This study aimed to evaluate the psychometric properties and measurement invariance of the Chinese version of the FACT/GOG-Ntx13 in patients with colorectal cancer receiving oxaliplatin-based chemotherapy.Methods A longitudinal quantitative survey was conducted among 534 Chinese patients with colorectal cancer. Data were collected one month and three months after the initiation of chemotherapy. Exploratory factor analysis, confirmatory factor analysis, measurement invariance testing, criterion validity analysis, and internal consistency reliability analysis were performed.Results Exploratory factor analysis supported a one-factor structure, which was further confirmed by confirmatory factor analysis with acceptable model fit at both time points. The scale demonstrated good criterion-related validity through its positive correlation with the EORTC QLQ-CIPN20 and showed good internal consistency at both assessments. Measurement invariance across gender was supported at configural, metric, and scalar levels. Longitudinally, configural and metric invariance were supported, whereas scalar invariance was not.Conclusion The Chinese version of the FACT/GOG-Ntx13 is a valid and reliable instrument for assessing oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer. However, changes in scores over time should be interpreted cautiously because longitudinal scalar invariance was not supported.
SN - 2509-8020
ER -