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Peer-reviewedCC BY-NCChemical Society Reviews

Organizing multivalency in carbohydrate recognition

Abstract

The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency.

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BibTeX
@article{muller2026organizing,
  title = {{Organizing multivalency in carbohydrate recognition}},
  author = {Christian Müller and Guillaume Guillaume Despras and Thisbe Lindhorst},
  journal = {Chemical Society Reviews},
  year = {2026},
  month = oct,
  doi = {10.1039/c6cs00165c},
  url = {https://hal.science/hal-05789011v1},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Organizing multivalency in carbohydrate recognition
AU  - Christian Müller
AU  - Guillaume Guillaume Despras
AU  - Thisbe Lindhorst
PY  - 2026
DA  - 2026/10/09
JO  - Chemical Society Reviews
DO  - 10.1039/c6cs00165c
UR  - https://hal.science/hal-05789011v1
AB  - The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency.
SN  - 0306-0012
SN  - 1460-4744
ER  -