A Researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives
Abstract
Rodent models of Down syndrome (DS) have been transformative in identifying basic mechanisms underlying the effects of Trisomy 21 at the molecular, cellular, physiological, and neurobehavioral levels. Each model, with its unique genomic architecture, has advanced our understanding of the complex multisystem etiology of DS. The availability of multiple models necessitates the challenge of selecting appropriate models to address a particular scientific question, experimental design, and translational relevance. This primer guides the reader through the various rodent models of DS and the genomic and phenotypic effects they recapitulate. We also provide recommendations and strategies for using DS rodent models to enable effective and robust forward and reverse translational approaches.
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BibTeX
@article{raza2026researchers,
title = {{A Researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives}},
author = {Mir Raza and Andrew Folz and Daniella Victorino and Zhuo Xing and Xu-Qiao Chen and Xinxin Zuo and Leah Borden and Marie-Claude Potier and William Mobley and Mara Dierssen and Masaharu Hiratsuka and Yasuhiro Kazuki and Kristy Welshhans and Michelle Maugham-Macan and Antonella Tramutola and Eitan Okun and Roger Reeves and Randall Roper and Y. Eugene Yu and Yann Hérault and Victor L.J. Tybulewicz and Elizabeth M.C. Fisher and Aaron Sathyanesan},
journal = {STAR Protocols},
year = {2026},
month = oct,
doi = {10.1016/j.xpro.2026.104717},
url = {https://hal.science/hal-05844245v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - A Researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives
AU - Mir Raza
AU - Andrew Folz
AU - Daniella Victorino
AU - Zhuo Xing
AU - Xu-Qiao Chen
AU - Xinxin Zuo
AU - Leah Borden
AU - Marie-Claude Potier
AU - William Mobley
AU - Mara Dierssen
AU - Masaharu Hiratsuka
AU - Yasuhiro Kazuki
AU - Kristy Welshhans
AU - Michelle Maugham-Macan
AU - Antonella Tramutola
AU - Eitan Okun
AU - Roger Reeves
AU - Randall Roper
AU - Y. Eugene Yu
AU - Yann Hérault
AU - Victor L.J. Tybulewicz
AU - Elizabeth M.C. Fisher
AU - Aaron Sathyanesan
PY - 2026
DA - 2026/10/29
JO - STAR Protocols
DO - 10.1016/j.xpro.2026.104717
UR - https://hal.science/hal-05844245v1
AB - Rodent models of Down syndrome (DS) have been transformative in identifying basic mechanisms underlying the effects of Trisomy 21 at the molecular, cellular, physiological, and neurobehavioral levels. Each model, with its unique genomic architecture, has advanced our understanding of the complex multisystem etiology of DS. The availability of multiple models necessitates the challenge of selecting appropriate models to address a particular scientific question, experimental design, and translational relevance. This primer guides the reader through the various rodent models of DS and the genomic and phenotypic effects they recapitulate. We also provide recommendations and strategies for using DS rodent models to enable effective and robust forward and reverse translational approaches.
SN - 2666-1667
ER -