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Peer-reviewedCC BYActa odontologica Scandinavica

Medication-related osteonecrosis of the jaw in cancer and osteoporosis patients: a retrospective seven-year single-center Norwegian cohort study of clinical profiles and documented soft tissue healing.

  • Safiyye Süslü1
  • Håvard J Haugen2
  • Tormod B Krüger3
  • Janne Elin Reseland1
  • Bente Brokstad Herlofson3
  1. 1Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
  2. 2Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway. [email protected].
  3. 3Department of Oral Medicine and Oral Surgery, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
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Abstract

Objective

To compare systemic profiles, oral findings, and documented soft tissue healing between cancer and osteoporosis patients with medication-related osteonecrosis of the jaw (MRONJ).Material and methods

This retrospective single-center cohort included 105 cases treated in 2013-2019 (56 cancer; 49 osteoporosis). Healing at last follow-up was analyzed using adjusted logistic regression and Firth sensitivity analysis.Results

Of 102 cases with known final status, 68 had documented healing. Osteoporosis cases were older, predominantly female, and had longer antiresorptive exposure than cancer cases (76.7 ± 11.1 vs. 70.0 ± 8.5 years; 102.5 ± 77.8 vs. 34.6 ± 28.5 months; both p < 0.001). Stage II predominated and Stage 0 was uncommon (3/105, 2.9%). Previous tooth extraction at the MRONJ lesion site was more frequent in osteoporosis (95.9% vs. 71.4%; p < 0.001). Surgical treatment was associated with higher healing odds (adjusted odds ratio [OR]: 11.12, 95% confidence interval [CI]: 4.12 to 33.35; p < 0.001), whereas cancer indication was associated with lower odds (adjusted OR: 0.23, 95% CI: 0.07 to 0.68; p = 0.011).Conclusions

Systemic profiles differed; oral patterns were similar. Non-random treatment and missing healing dates limit interpretation. Previous tooth extraction was the most frequent antecedent event; its indication and timing were unverified.

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Cite

BibTeXRIS
BibTeX
@article{suslu2026medicationrelated,
  title = {{Medication-related osteonecrosis of the jaw in cancer and osteoporosis patients: a retrospective seven-year single-center Norwegian cohort study of clinical profiles and documented soft tissue healing.}},
  author = {Safiyye Süslü and Håvard J Haugen and Tormod B Krüger and Janne Elin Reseland and Bente Brokstad Herlofson},
  journal = {Acta odontologica Scandinavica},
  year = {2026},
  month = oct,
  doi = {10.2340/aos.v85.46983},
  url = {https://europepmc.org/article/MED/42852807},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Medication-related osteonecrosis of the jaw in cancer and osteoporosis patients: a retrospective seven-year single-center Norwegian cohort study of clinical profiles and documented soft tissue healing.
AU  - Safiyye Süslü
AU  - Håvard J Haugen
AU  - Tormod B Krüger
AU  - Janne Elin Reseland
AU  - Bente Brokstad Herlofson
PY  - 2026
DA  - 2026/10/09
JO  - Acta odontologica Scandinavica
DO  - 10.2340/aos.v85.46983
UR  - https://europepmc.org/article/MED/42852807
AB  - Objective  To compare systemic profiles, oral findings, and documented soft tissue healing between cancer and osteoporosis patients with medication-related osteonecrosis of the jaw (MRONJ).Material and methods  This retrospective single-center cohort included 105 cases treated in 2013-2019 (56 cancer; 49 osteoporosis). Healing at last follow-up was analyzed using adjusted logistic regression and Firth sensitivity analysis.Results  Of 102 cases with known final status, 68 had documented healing. Osteoporosis cases were older, predominantly female, and had longer antiresorptive exposure than cancer cases (76.7 ± 11.1 vs. 70.0 ± 8.5 years; 102.5 ± 77.8 vs. 34.6 ± 28.5 months; both p < 0.001). Stage II predominated and Stage 0 was uncommon (3/105, 2.9%). Previous tooth extraction at the MRONJ lesion site was more frequent in osteoporosis (95.9% vs. 71.4%; p < 0.001). Surgical treatment was associated with higher healing odds (adjusted odds ratio [OR]: 11.12, 95% confidence interval [CI]: 4.12 to 33.35; p < 0.001), whereas cancer indication was associated with lower odds (adjusted OR: 0.23, 95% CI: 0.07 to 0.68; p = 0.011).Conclusions  Systemic profiles differed; oral patterns were similar. Non-random treatment and missing healing dates limit interpretation. Previous tooth extraction was the most frequent antecedent event; its indication and timing were unverified.
SN  - 0001-6357
SN  - 1502-3850
ER  -