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Peer-reviewedCC BY-NCAnnals of coloproctology

Transverse colon cancer as an independent predictor of locoregional recurrence in patients with stage III colon cancer: a retrospective cohort study.

  • Min Hyeong Jo1
  • Kyong-Min Kang2
  • Mi Jeong Choi2
  • Hye-Rim Shin2
  • Tae-Gyun Lee3
  • Hong-Min Ahn2
  • Heung-Kwon Oh2
  • Duck-Woo Kim2
  • Sung-Bum Kang2
  1. 1Department of Surgery, Ewha Womans University College of Medicine, Seoul, Korea
  2. 2Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea
  3. 3Department of Surgery, Ajou University School of Medicine, Suwon, Korea
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Abstract

Purpose

This study aimed to evaluate the significance of transverse colon cancer as a predictor of locoregional recurrence in patients with stage III colon cancer.Methods

This single-center retrospective cohort study included 1,302 patients who underwent curative-intent laparoscopic colectomy for stage III colon cancer between 2003 and 2021. The primary outcome was locoregional recurrence, defined as tumor recurrence near the anastomotic site, regional lymph nodes, or peritoneal recurrence around the primary tumor. Multivariate analyses were conducted to identify the factors associated with locoregional recurrence.Results

Transverse colon cancer was identified in 151 patients (11.6%). Baseline characteristics were similar, but transverse colon cancer exhibited a higher locoregional recurrence rate than nontransverse colon cancer (7.9% vs. 2.0%, P<0.001). In transverse colon cancer, locoregional recurrence did not differ according to high ligation of the mid-colic vessel (without high ligation, 10.6% vs. high ligation, 6.7%; P=0.517), and 10 of 12 recurrences (83.3%) occurred predominantly in the regional lymph nodes. In multivariate analysis, transverse colon (hazard ratio [HR], 4.513; 95% confidence interval [CI], 2.226-9.154; P<0.001) and N2 category (HR, 2.044; 95% CI, 1.034-4.042; P=0.040) emerged as independent predictors of locoregional recurrence. Disease-free survival (73.8% vs. 79.2%, P=0.217) and overall survival (84.7% vs. 86.3%, P=0.735) in 5 years were not different between transverse and nontransverse colon cancer.Conclusion

Transverse colon cancer may serve as an independent predictor of locoregional recurrence in stage III colon cancer. The predominance of regional lymph node recurrence emphasizes the importance of careful regional lymph node assessment in transverse colon cancer.

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Cite

BibTeXRIS
BibTeX
@article{jo2026transverse,
  title = {{Transverse colon cancer as an independent predictor of locoregional recurrence in patients with stage III colon cancer: a retrospective cohort study.}},
  author = {Min Hyeong Jo and Kyong-Min Kang and Mi Jeong Choi and Hye-Rim Shin and Tae-Gyun Lee and Hong-Min Ahn and Heung-Kwon Oh and Duck-Woo Kim and Sung-Bum Kang},
  journal = {Annals of coloproctology},
  year = {2026},
  month = oct,
  doi = {10.3393/ac.2026.00325.0046},
  url = {https://europepmc.org/article/MED/42958782},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Transverse colon cancer as an independent predictor of locoregional recurrence in patients with stage III colon cancer: a retrospective cohort study.
AU  - Min Hyeong Jo
AU  - Kyong-Min Kang
AU  - Mi Jeong Choi
AU  - Hye-Rim Shin
AU  - Tae-Gyun Lee
AU  - Hong-Min Ahn
AU  - Heung-Kwon Oh
AU  - Duck-Woo Kim
AU  - Sung-Bum Kang
PY  - 2026
DA  - 2026/10/01
JO  - Annals of coloproctology
DO  - 10.3393/ac.2026.00325.0046
UR  - https://europepmc.org/article/MED/42958782
AB  - Purpose  This study aimed to evaluate the significance of transverse colon cancer as a predictor of locoregional recurrence in patients with stage III colon cancer.Methods  This single-center retrospective cohort study included 1,302 patients who underwent curative-intent laparoscopic colectomy for stage III colon cancer between 2003 and 2021. The primary outcome was locoregional recurrence, defined as tumor recurrence near the anastomotic site, regional lymph nodes, or peritoneal recurrence around the primary tumor. Multivariate analyses were conducted to identify the factors associated with locoregional recurrence.Results  Transverse colon cancer was identified in 151 patients (11.6%). Baseline characteristics were similar, but transverse colon cancer exhibited a higher locoregional recurrence rate than nontransverse colon cancer (7.9% vs. 2.0%, P<0.001). In transverse colon cancer, locoregional recurrence did not differ according to high ligation of the mid-colic vessel (without high ligation, 10.6% vs. high ligation, 6.7%; P=0.517), and 10 of 12 recurrences (83.3%) occurred predominantly in the regional lymph nodes. In multivariate analysis, transverse colon (hazard ratio [HR], 4.513; 95% confidence interval [CI], 2.226-9.154; P<0.001) and N2 category (HR, 2.044; 95% CI, 1.034-4.042; P=0.040) emerged as independent predictors of locoregional recurrence. Disease-free survival (73.8% vs. 79.2%, P=0.217) and overall survival (84.7% vs. 86.3%, P=0.735) in 5 years were not different between transverse and nontransverse colon cancer.Conclusion  Transverse colon cancer may serve as an independent predictor of locoregional recurrence in stage III colon cancer. The predominance of regional lymph node recurrence emphasizes the importance of careful regional lymph node assessment in transverse colon cancer.
SN  - 2287-9714
SN  - 2287-9722
ER  -