A Low HALP score is an independent predictor of coronary artery ectasia: a retrospective comparative study.
- 1Etlik City Hospital, Department of Cardiology, Ankara, Turkey.
- 2Faculty of Medicine, Department of Cardiology, Kırıkkale University, Kırıkkale, Turkey. [email protected].
Abstract
Background
We aimed to determine whether the hemoglobin, albumin, lymphocyte, and platelet (HALP) score is independently associated with the presence and angiographic severity of coronary artery ectasia (CAE), and to assess its potential role as a diagnostic inflammatory-nutritional biomarker in this population.Methods
In this retrospective, single-center study, the hemoglobin, albumin, lymphocyte, and platelet (HALP) scores were calculated using routine laboratory parameters obtained at admission. Logistic regression models were constructed to identify independent predictors of CAE. Furthermore, receiver operating characteristic (ROC) analysis was performed to determine the diagnostic performance of the HALP score, and the association between the HALP score and the angiographic extent of CAE was evaluated.Results
Among 628 patients (290 CAE, 338 controls), the median HALP score was significantly lower in the CAE group (4.14 vs. 4.99, p < 0.001). Multivariate analysis identified a lower HALP score as an independent predictor of CAE (OR: 0.752, 95% CI: 0.655-0.865, p < 0.001). A HALP score of 4.569 predicted CAE with 60.1% sensitivity and 57.2% specificity (AUC: 0.650). The score was not associated with the angiographic extent of CAE (p = 0.461).Conclusion
In conclusion, a low HALP score is significantly and independently associated with the presence of coronary artery ectasia in patients without obstructive coronary artery disease, reflecting the underlying systemic inflammatory and nutritional milieu. This easily obtainable index may serve as a useful complementary biomarker for assessing inflammatory burden in CAE patients, although further large-scale prospective studies are warranted to confirm its prognostic and clinical utility.Trial registration
Not applicable. This study is a retrospective observational analysis and does not report the results of a health care intervention.
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BibTeX
@article{akdogan2026halp,
title = {{A Low HALP score is an independent predictor of coronary artery ectasia: a retrospective comparative study.}},
author = {Murat Akdoğan and Hüseyin Kandemi̇r and Onur Akgün and İbrahim Halil Uygun},
journal = {BMC cardiovascular disorders},
year = {2026},
month = aug,
doi = {10.1186/s12872-026-06394-4},
url = {https://europepmc.org/article/MED/42972242},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - A Low HALP score is an independent predictor of coronary artery ectasia: a retrospective comparative study.
AU - Murat Akdoğan
AU - Hüseyin Kandemi̇r
AU - Onur Akgün
AU - İbrahim Halil Uygun
PY - 2026
DA - 2026/08/06
JO - BMC cardiovascular disorders
DO - 10.1186/s12872-026-06394-4
UR - https://europepmc.org/article/MED/42972242
AB - Background We aimed to determine whether the hemoglobin, albumin, lymphocyte, and platelet (HALP) score is independently associated with the presence and angiographic severity of coronary artery ectasia (CAE), and to assess its potential role as a diagnostic inflammatory-nutritional biomarker in this population.Methods In this retrospective, single-center study, the hemoglobin, albumin, lymphocyte, and platelet (HALP) scores were calculated using routine laboratory parameters obtained at admission. Logistic regression models were constructed to identify independent predictors of CAE. Furthermore, receiver operating characteristic (ROC) analysis was performed to determine the diagnostic performance of the HALP score, and the association between the HALP score and the angiographic extent of CAE was evaluated.Results Among 628 patients (290 CAE, 338 controls), the median HALP score was significantly lower in the CAE group (4.14 vs. 4.99, p < 0.001). Multivariate analysis identified a lower HALP score as an independent predictor of CAE (OR: 0.752, 95% CI: 0.655-0.865, p < 0.001). A HALP score of 4.569 predicted CAE with 60.1% sensitivity and 57.2% specificity (AUC: 0.650). The score was not associated with the angiographic extent of CAE (p = 0.461).Conclusion In conclusion, a low HALP score is significantly and independently associated with the presence of coronary artery ectasia in patients without obstructive coronary artery disease, reflecting the underlying systemic inflammatory and nutritional milieu. This easily obtainable index may serve as a useful complementary biomarker for assessing inflammatory burden in CAE patients, although further large-scale prospective studies are warranted to confirm its prognostic and clinical utility.Trial registration Not applicable. This study is a retrospective observational analysis and does not report the results of a health care intervention.
SN - 1471-2261
ER -