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Peer-reviewedCC BY 4.0Frontiers in Neurology

Herbal-derived bioactive compounds in stroke recovery: from neuroprotective mechanisms to clinical evidence and translational challenges

  • Xi-zhe Sun1
  • Jia-lu Lv2
  • Lan-xin Gu3
  • Ya-ge Li4
  • Xiao-mao Li5
  • Ye Li6
  • Yu-meng Luo2,7
7 affiliations
  1. 1Drug Research and Development Technology Park, Hainan Medical University, Haikou
  2. 2Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine
  3. 3The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin
  4. 4Traditional Chinese Medicine College, Bozhou University
  5. 5School of Pharmacy, Jiangsu Food and Pharmaceutical Science College, Huai'an
  6. 6College of Pharmacy, Chongqing Three Gorges Medical College
  7. 7Traditional Chinese Medicine Biological Genetics, Heilongjiang Province Double First-Class Construction Interdiscipline
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Abstract

Stroke is a leading cause of death and long-term disability worldwide, driven by pathophysiological processes including excitotoxicity, oxidative stress, neuroinflammation and apoptosis. Current pharmacological and non-pharmacological interventions primarily restore perfusion or support rehabilitation but do not fully address multifactorial secondary injury. Herbal-derived bioactive compounds possess antioxidant, anti-inflammatory and neuroprotective activities. Preclinical studies show that they limit neuronal injury and modulate excitotoxicity, oxidative stress, neuroinflammation, apoptosis, blood–brain barrier disruption and angiogenesis. Clinical trials suggest that these compounds can complement conventional treatment and improve functional or cognitive outcomes. This review synthesizes evidence on their mechanisms of action, therapeutic roles, combination strategies and research gaps. Herbal-derived bioactive compounds offer accessible adjuncts for stroke management, but their safe and effective integration into rehabilitation practice requires formulation standardization and large-scale clinical trials.

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Cite

BibTeXRIS
BibTeX
@article{sun2026herbalderived,
  title = {{Herbal-derived bioactive compounds in stroke recovery: from neuroprotective mechanisms to clinical evidence and translational challenges}},
  author = {Xi-zhe Sun and Jia-lu Lv and Lan-xin Gu and Ya-ge Li and Xiao-mao Li and Ye Li and Yu-meng Luo},
  journal = {Frontiers in Neurology},
  year = {2026},
  month = oct,
  doi = {10.3389/fneur.2026.1902978},
  url = {https://www.frontiersin.org/articles/10.3389/fneur.2026.1902978/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Herbal-derived bioactive compounds in stroke recovery: from neuroprotective mechanisms to clinical evidence and translational challenges
AU  - Xi-zhe Sun
AU  - Jia-lu Lv
AU  - Lan-xin Gu
AU  - Ya-ge Li
AU  - Xiao-mao Li
AU  - Ye Li
AU  - Yu-meng Luo
PY  - 2026
DA  - 2026/10/16
JO  - Frontiers in Neurology
DO  - 10.3389/fneur.2026.1902978
UR  - https://www.frontiersin.org/articles/10.3389/fneur.2026.1902978/full
AB  - Stroke is a leading cause of death and long-term disability worldwide, driven by pathophysiological processes including excitotoxicity, oxidative stress, neuroinflammation and apoptosis. Current pharmacological and non-pharmacological interventions primarily restore perfusion or support rehabilitation but do not fully address multifactorial secondary injury. Herbal-derived bioactive compounds possess antioxidant, anti-inflammatory and neuroprotective activities. Preclinical studies show that they limit neuronal injury and modulate excitotoxicity, oxidative stress, neuroinflammation, apoptosis, blood–brain barrier disruption and angiogenesis. Clinical trials suggest that these compounds can complement conventional treatment and improve functional or cognitive outcomes. This review synthesizes evidence on their mechanisms of action, therapeutic roles, combination strategies and research gaps. Herbal-derived bioactive compounds offer accessible adjuncts for stroke management, but their safe and effective integration into rehabilitation practice requires formulation standardization and large-scale clinical trials.
SN  - 1664-2295
ER  -