Skip to content
DraconiticResearch
Search Sources API
178,970 studies31 sourcesUpdated 54 min ago
Peer-reviewedCC BY 4.0Frontiers in Immunology

m6A modification in allergic airway diseases: a narrative review from a cellular perspective

  • Leilei Zheng1,2,3
  • Siyu Duan1,2,3
  • Ziyi Jia1,2,3
  • Zhihan Xu1,2,3
  • Yisha Wu1,2,3
  • Shikai Han1,2,3
  • Jinmei Xue1,2,3
  1. 1Department of Otolaryngology, Head and Neck Surgery, the Second Hospital, Shanxi Medical University
  2. 2Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases
  3. 3Shanxi Medical University
Open at sourceDOICite

Abstract

N6-methyladenosine (m6A) represents the most prevalent modification on eukaryotic RNA and plays a critical role in nearly all stages of RNA expression regulation. Extensive research demonstrates that the dysregulation of m6A modification plays a significant role in the disruption of epithelial barriers, the induction of oxidative stress, the activation of inflammatory cells, and the remodeling of airways, all of which are characteristic pathological features of allergic airway diseases (AADs). Given the distinct roles of various cell types in the progression and resolution of AADs, understanding how m6A functions across cellular contexts is essential for a comprehensive understanding of the disease’s pathological mechanisms. This review begins by outlining the fundamental biological characteristics of m6A modification. Subsequently, we explore how dynamic m6A modifications affect AADs progression from the perspectives of airway epithelial cells, innate immune cells, and adaptive immune cells, emphasizing the pivotal regulatory role of m6A in epithelial-immune crosstalk. We then summarize how cellular context shapes the functional heterogeneity of m6A modification and discuss the potential underlying mechanisms. Finally, we summarize the latest progress in the use of m6A-related enzymes as tools for disease prediction, therapeutic intervention, and evaluation of allergen immunotherapy efficacy, and discuss the opportunities and challenges associated with the clinical translation of m6A-targeted therapeutic strategies.

Related

  1. M6A modification in lipid metabolism and related diseases
    Zhiwen Hu, Didi Yuan, Xi Feng +1
    Frontiers in geneticsPeer-reviewedCC BYFull textGeneral biochemistryEurope PMC
  2. New perspective on epigenetic modification and immunotherapy in endometrial cancer.
    Haoqian Zhang, Dandan Shen, Nanshan Lin +2
    Clinical epigeneticsPeer-reviewedCC BY-NC-NDFull textMolecular biology & gene regulationEurope PMCDOAJ
  3. The Role of the Gut–Liver Axis in the Development of Liver Diseases Induced by Selected Environmental Pollutants: A Narrative Review
    Sara Jarmakiewicz-Czaja, Kübra Ergan, Aneta Sokal-Dembowska
    International journal of molecular sciencesPeer-reviewedCC BYFull textGeneral biochemistryEurope PMC
  4. Phenotypes of Atopic Dermatitis and Development of Allergic Diseases
    A. R. Sitarik, A. A. Eapen, J. M. Biagini +22
    JAMA Network OpenPeer-reviewedCC BYFull text17 citedGeneral biochemistryGeneral biologyHAL
  5. Gut Microbiota and Nutritional Aspects in Pancreatic Diseases: A Narrative Review
    Klara Szwarc, Joanna Witkowska, Agnieszka Dobrowolska +1
    NutrientsPeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMCCrossref

Cite

BibTeXRIS
BibTeX
@article{zheng2026modification,
  title = {{m6A modification in allergic airway diseases: a narrative review from a cellular perspective}},
  author = {Leilei Zheng and Siyu Duan and Ziyi Jia and Zhihan Xu and Yisha Wu and Shikai Han and Jinmei Xue},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1943431},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1943431/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - m6A modification in allergic airway diseases: a narrative review from a cellular perspective
AU  - Leilei Zheng
AU  - Siyu Duan
AU  - Ziyi Jia
AU  - Zhihan Xu
AU  - Yisha Wu
AU  - Shikai Han
AU  - Jinmei Xue
PY  - 2026
DA  - 2026/10/21
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1943431
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1943431/full
AB  - N6-methyladenosine (m6A) represents the most prevalent modification on eukaryotic RNA and plays a critical role in nearly all stages of RNA expression regulation. Extensive research demonstrates that the dysregulation of m6A modification plays a significant role in the disruption of epithelial barriers, the induction of oxidative stress, the activation of inflammatory cells, and the remodeling of airways, all of which are characteristic pathological features of allergic airway diseases (AADs). Given the distinct roles of various cell types in the progression and resolution of AADs, understanding how m6A functions across cellular contexts is essential for a comprehensive understanding of the disease’s pathological mechanisms. This review begins by outlining the fundamental biological characteristics of m6A modification. Subsequently, we explore how dynamic m6A modifications affect AADs progression from the perspectives of airway epithelial cells, innate immune cells, and adaptive immune cells, emphasizing the pivotal regulatory role of m6A in epithelial-immune crosstalk. We then summarize how cellular context shapes the functional heterogeneity of m6A modification and discuss the potential underlying mechanisms. Finally, we summarize the latest progress in the use of m6A-related enzymes as tools for disease prediction, therapeutic intervention, and evaluation of allergen immunotherapy efficacy, and discuss the opportunities and challenges associated with the clinical translation of m6A-targeted therapeutic strategies.
SN  - 1664-3224
ER  -