Self-rolling film for in vivo drug delivery to limit colonic inflammation induced after radiation exposure
Abstract
Radiotherapy is a cornerstone of cancer treatment; however, despite major technological advances, radiation-induced injury to surrounding healthy tissues remains a significant clinical challenge. Here, we developed a preclinical rat model of radiation proctitis using localized, fractionated colorectal irradiation followed by comprehensive histopathological characterization. To enable local drug delivery while minimizing systemic exposure, we engineered a self-rolling bilayer PEG-PLA film loaded with the anti-inflammatory drug prednisolone. The biomaterial was optimized for endoscopic implantation into the irradiated colorectum, providing a minimally invasive therapeutic approach. Local administration of prednisolone significantly reduced the secretion of pro-inflammatory cytokines, including IL-1β, within the colonic mucosa, demonstrating the efficacy of the device in attenuating radiation-induced inflammation. Beyond prednisolone delivery, this adaptable platform could support localized administration of a broad range of therapeutic agents, including biologics or other compounds whose systemic use is limited by toxicity, poor tolerability, or high cost.
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BibTeX
@article{amarantesilva2026selfrolling,
title = {{Self-rolling film for in vivo drug delivery to limit colonic inflammation induced after radiation exposure}},
author = {Diego Amarante-Silva and Christelle Demarquay and Benjamin Nottelet and Mathilde Grosjean and Sidzigui Ouedraogo and Fabien Milliat and Karine Anselme and Arnaud Ponche and Noëlle Mathieu},
journal = {iScience},
year = {2026},
month = sep,
doi = {10.1016/j.isci.2026.117453},
url = {https://asnr.hal.science/hal-05769354v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Self-rolling film for in vivo drug delivery to limit colonic inflammation induced after radiation exposure
AU - Diego Amarante-Silva
AU - Christelle Demarquay
AU - Benjamin Nottelet
AU - Mathilde Grosjean
AU - Sidzigui Ouedraogo
AU - Fabien Milliat
AU - Karine Anselme
AU - Arnaud Ponche
AU - Noëlle Mathieu
PY - 2026
DA - 2026/09/03
JO - iScience
DO - 10.1016/j.isci.2026.117453
UR - https://asnr.hal.science/hal-05769354v1
AB - Radiotherapy is a cornerstone of cancer treatment; however, despite major technological advances, radiation-induced injury to surrounding healthy tissues remains a significant clinical challenge. Here, we developed a preclinical rat model of radiation proctitis using localized, fractionated colorectal irradiation followed by comprehensive histopathological characterization. To enable local drug delivery while minimizing systemic exposure, we engineered a self-rolling bilayer PEG-PLA film loaded with the anti-inflammatory drug prednisolone. The biomaterial was optimized for endoscopic implantation into the irradiated colorectum, providing a minimally invasive therapeutic approach. Local administration of prednisolone significantly reduced the secretion of pro-inflammatory cytokines, including IL-1β, within the colonic mucosa, demonstrating the efficacy of the device in attenuating radiation-induced inflammation. Beyond prednisolone delivery, this adaptable platform could support localized administration of a broad range of therapeutic agents, including biologics or other compounds whose systemic use is limited by toxicity, poor tolerability, or high cost.
SN - 2589-0042
ER -