Isolation, Structural Elucidation, and Anti-Melanogenic Activity of a Novel Pectic Polysaccharide From Alhagi camelorum Fisch.
- 1State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
- 2University of Chinese Academy of Sciences, Beijing, China.
- 3Qinghai Normal University, Xining, China.
Abstract
Hyperpigmentation disorders motivate the search for structurally defined and effective natural depigmenting agents from plant-derived polysaccharides. The present study characterized the structural features and evaluated the anti-melanogenic activity of ACP-II-1, a novel pectic polysaccharide isolated from Alhagi camelorum Fisch. ACP-II-1 had a molecular weight of 26.145 kDa and contained GalA, Rha, Gal, Ara, GlcA, and Xyl at respective molar proportions of 0.798, 0.072, 0.053, 0.052, 0.016, and 0.009. Integrated monosaccharide, methylation, FT-IR, and NMR analyses indicated a GalA-rich structure dominated by homogalacturonan (HG)-type →4)-α-D-GalpA-(1→ sequences, with less abundant branched rhamnogalacturonan-I (RG-I)-type motifs and heterogeneous neutral side-chain motifs. In forskolin-stimulated B16F10 cells, ACP-II-1 significantly lowered melanin content and cellular tyrosinase activity; it also decreased pigmentation and tyrosinase activity in zebrafish. These effects in B16F10 cells coincided with lower MITF, TYR, TRP-1, and TRP-2 protein levels, together with altered readouts associated with GSK-3β/β-catenin, PKA/CREB, and p38/JNK signaling. Collectively, these findings support the anti-melanogenic potential of ACP-II-1 and warrant further validation in mammalian and human-relevant skin models, together with comprehensive safety evaluation.
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BibTeX
@article{liu2026isolation,
title = {{Isolation, Structural Elucidation, and Anti-Melanogenic Activity of a Novel Pectic Polysaccharide From Alhagi camelorum Fisch.}},
author = {Zhitao Liu and Shuyan Han and Nannan Xu and Nuermaimaiti Abudukelimu and Jiangyu Zhao},
journal = {Chemistry \& biodiversity},
year = {2026},
month = oct,
doi = {10.1002/cbdv.71878},
url = {https://europepmc.org/article/MED/42960694},
note = {CC BY},
}
RIS
TY - JOUR
TI - Isolation, Structural Elucidation, and Anti-Melanogenic Activity of a Novel Pectic Polysaccharide From Alhagi camelorum Fisch.
AU - Zhitao Liu
AU - Shuyan Han
AU - Nannan Xu
AU - Nuermaimaiti Abudukelimu
AU - Jiangyu Zhao
PY - 2026
DA - 2026/10/30
JO - Chemistry & biodiversity
DO - 10.1002/cbdv.71878
UR - https://europepmc.org/article/MED/42960694
AB - Hyperpigmentation disorders motivate the search for structurally defined and effective natural depigmenting agents from plant-derived polysaccharides. The present study characterized the structural features and evaluated the anti-melanogenic activity of ACP-II-1, a novel pectic polysaccharide isolated from Alhagi camelorum Fisch. ACP-II-1 had a molecular weight of 26.145 kDa and contained GalA, Rha, Gal, Ara, GlcA, and Xyl at respective molar proportions of 0.798, 0.072, 0.053, 0.052, 0.016, and 0.009. Integrated monosaccharide, methylation, FT-IR, and NMR analyses indicated a GalA-rich structure dominated by homogalacturonan (HG)-type →4)-α-D-GalpA-(1→ sequences, with less abundant branched rhamnogalacturonan-I (RG-I)-type motifs and heterogeneous neutral side-chain motifs. In forskolin-stimulated B16F10 cells, ACP-II-1 significantly lowered melanin content and cellular tyrosinase activity; it also decreased pigmentation and tyrosinase activity in zebrafish. These effects in B16F10 cells coincided with lower MITF, TYR, TRP-1, and TRP-2 protein levels, together with altered readouts associated with GSK-3β/β-catenin, PKA/CREB, and p38/JNK signaling. Collectively, these findings support the anti-melanogenic potential of ACP-II-1 and warrant further validation in mammalian and human-relevant skin models, together with comprehensive safety evaluation.
SN - 1612-1872
SN - 1612-1880
ER -