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Peer-reviewedCC BY-NCAnnals of dermatology

Antibacterial, Anti-Inflammatory and Anti-Melanogenic Effects of a Novel Peptide.

  • Mina Song1
  • Jeong Hyeon Lee1
  • Si-Eun Park2
  • Jung Im Lee3
  • Youngsup Song4
  • Sung Eun Chang5
5 affiliations
  1. 1Department of Dermatology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  2. 2Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  3. 3Dermafirm Inc., Derma Science Lab, Ltd., Seoul, Korea.
  4. 4Department of Brain Sciences, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. [email protected].
  5. 5Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. [email protected].
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Abstract

Background

Acne-induced post-inflammatory hyperpigmentation (PIH) is driven by Cutibacterium acnes-mediated inflammation and dysregulated melanogenesis; however, effective treatments targeting both processes remain limited.Objective

This study aimed to evaluate the anti-bacterial, anti-inflammatory, and anti-melanogenic effects of a newly made 2-isopropyl-5-methylphenol-conjugated valine-tryptophan dipeptide (2IP5MP-VW).Methods

IPMP-VW conjugates were synthesized and screened for antibacterial activity against C. acnes. The effects of 2IP5MP-VW on inflammation and melanogenesis were assessed using Raw 264.7 macrophages and Mel-ab cells, and ex-vivo human skin.Results

Among the synthesized candidates, 2IP5MP-VW showed the strongest antibacterial activity against C. acnes. 2IP5MP-VW suppressed lipopolysaccharide-induced nitric oxide (NO) production via downregulation of inducible NO synthase without cytotoxicity. It also reduced melanin content in both unstimulated and forskolin-stimulated melanocytes. In ex vivo human skin, 2IP5MP-VW showed a decreasing trend in ultraviolet B-induced melanin accumulation.Conclusion

2IP5MP-VW exhibits multifunctional anti-bacterial, anti-inflammatory, and anti-melanogenic activities, suggesting its potential as a candidate for the management of acne-induced PIH.

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Cite

BibTeXRIS
BibTeX
@article{song2026antibacterial,
  title = {{Antibacterial, Anti-Inflammatory and Anti-Melanogenic Effects of a Novel Peptide.}},
  author = {Mina Song and Jeong Hyeon Lee and Si-Eun Park and Jung Im Lee and Youngsup Song and Sung Eun Chang},
  journal = {Annals of dermatology},
  year = {2026},
  month = oct,
  doi = {10.5021/ad.26.029},
  url = {https://europepmc.org/article/MED/42845207},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Antibacterial, Anti-Inflammatory and Anti-Melanogenic Effects of a Novel Peptide.
AU  - Mina Song
AU  - Jeong Hyeon Lee
AU  - Si-Eun Park
AU  - Jung Im Lee
AU  - Youngsup Song
AU  - Sung Eun Chang
PY  - 2026
DA  - 2026/10/01
JO  - Annals of dermatology
DO  - 10.5021/ad.26.029
UR  - https://europepmc.org/article/MED/42845207
AB  - Background  Acne-induced post-inflammatory hyperpigmentation (PIH) is driven by Cutibacterium acnes-mediated inflammation and dysregulated melanogenesis; however, effective treatments targeting both processes remain limited.Objective  This study aimed to evaluate the anti-bacterial, anti-inflammatory, and anti-melanogenic effects of a newly made 2-isopropyl-5-methylphenol-conjugated valine-tryptophan dipeptide (2IP5MP-VW).Methods  IPMP-VW conjugates were synthesized and screened for antibacterial activity against C. acnes. The effects of 2IP5MP-VW on inflammation and melanogenesis were assessed using Raw 264.7 macrophages and Mel-ab cells, and ex-vivo human skin.Results  Among the synthesized candidates, 2IP5MP-VW showed the strongest antibacterial activity against C. acnes. 2IP5MP-VW suppressed lipopolysaccharide-induced nitric oxide (NO) production via downregulation of inducible NO synthase without cytotoxicity. It also reduced melanin content in both unstimulated and forskolin-stimulated melanocytes. In ex vivo human skin, 2IP5MP-VW showed a decreasing trend in ultraviolet B-induced melanin accumulation.Conclusion  2IP5MP-VW exhibits multifunctional anti-bacterial, anti-inflammatory, and anti-melanogenic activities, suggesting its potential as a candidate for the management of acne-induced PIH.
SN  - 1013-9087
SN  - 2005-3894
ER  -