Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 49 min ago
Peer-reviewedCC BYOrganic letters

Direct C1-H Amination of Free NH Carbazoles Enabled by the Catellani Reaction.

  • Ganesh Shivayogappa Sorabad1
  • Paolo Pio Mazzeo2
  • Elena Motti1
  • Nicola Della Ca'1
  1. 1SynCat Lab, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124Parma (PR), Italy.
  2. 2Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124Parma (PR), Italy.
Read full textPDFDOICite

Abstract

Carbazoles are valuable building blocks for emerging pharmaceuticals and bioactive compounds. However, methods to access C1-H-aminated carbazoles remain underdeveloped. Current approaches often require multistep syntheses or the use of toxic metals. Herein, we report the first Pd/NBE-catalyzed C1-H amination of NH-free carbazoles. The method introduces a broad range of cyclic amines onto carbazole scaffold and tolerates several functional groups, including acyl, pivaloyl, and halogen substituents. This approach expands the scope of the Catellani reactions to the direct amination of unprotected carbazoles, offering a concise entry to otherwise challenging C1-aminated scaffolds.

Related

  1. Direct Mechanochemical Aryl Amination of Polystyrene for Creep Resistant Imine Elastomers
    Morgan Skala, Adelle Koenig, Gabriel Soto +1
    ChemRxivPreprintCC BYFull textMaterials & polymersChemRxiv
  2. Interrupted C(sp2) Ritter Reaction Enabled by a Stable Nitrilium Surrogate.
    Atul K Chaturvedi, Andrew J D Lacey, Alexi T Sedikides +1
    Journal of the American Chemical SocietyPeer-reviewedCC BYFull textPhysical chemistryEurope PMC
  3. Hydrogen‐Bond Enabled Phosphite Based Intrinsic Flame‐Retardant Solid‐Solid Phase Change Materials Using Catalyst/Solvent‐Free Multi‐Component Reaction for Battery Thermal Management
    Changhui Liu, Guangyuan Liang, Yuanzheng Liu +7
    Advanced SciencePeer-reviewedCC BY 4.0Full text1 citedMaterials & polymersPMC
  4. Recent advances in Catellani-type reactions for the construction of valuable polycyclic scaffolds (2017-2026)
    Shanshan Liu, Sébastien Prévost
    Tetrahedron ChemPeer-reviewedCC BY-NC-ND 4.0Full textCatalysisOrganic chemistryHAL
  5. Hydrogen-Assisted Reduction of Metal Oxides: Reaction Mechanisms, Process Optimization, and AI/ML-Enabled Pathways for Sustainable Materials Processing
    Kunal Mondal, Rigoberto C. Advincula, Prabhat K. Tripathy +1
    ChemRxivPreprintCC BYFull textGeneral chemistryChemRxiv

Cite

BibTeXRIS
BibTeX
@article{sorabad2026direct,
  title = {{Direct C1-H Amination of Free NH Carbazoles Enabled by the Catellani Reaction.}},
  author = {Ganesh Shivayogappa Sorabad and Paolo Pio Mazzeo and Elena Motti and Nicola Della Ca'},
  journal = {Organic letters},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.orglett.6c03473},
  url = {https://europepmc.org/article/MED/42917815},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Direct C1-H Amination of Free NH Carbazoles Enabled by the Catellani Reaction.
AU  - Ganesh Shivayogappa Sorabad
AU  - Paolo Pio Mazzeo
AU  - Elena Motti
AU  - Nicola Della Ca'
PY  - 2026
DA  - 2026/10/01
JO  - Organic letters
DO  - 10.1021/acs.orglett.6c03473
UR  - https://europepmc.org/article/MED/42917815
AB  - Carbazoles are valuable building blocks for emerging pharmaceuticals and bioactive compounds. However, methods to access C1-H-aminated carbazoles remain underdeveloped. Current approaches often require multistep syntheses or the use of toxic metals. Herein, we report the first Pd/NBE-catalyzed C1-H amination of NH-free carbazoles. The method introduces a broad range of cyclic amines onto carbazole scaffold and tolerates several functional groups, including acyl, pivaloyl, and halogen substituents. This approach expands the scope of the Catellani reactions to the direct amination of unprotected carbazoles, offering a concise entry to otherwise challenging C1-aminated scaffolds.
SN  - 1523-7060
SN  - 1523-7052
ER  -