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Peer-reviewedCC BYCureus

Assessment of QT Dispersion in Patients With Acute Myocardial Infarction

  • Akshara Ravichetti1
  • Viswajeeth Kalivela1
  • Madhu Yasarapu2
  • Aishwarya Mantri3
  • Shubham Jaju4
4 affiliations
  1. 1General Medicine, Osmania Medical College, Hyderabad, IND
  2. 2Pharmacology, Government Medical College, Suryapet, Suryapet, IND
  3. 3Pathology, Pacific Institute of Medical Sciences, Sai Tirupati University, Udaipur, IND
  4. 4Pharmacology, Pacific Institute of Medical Sciences, Sai Tirupati University, Udaipur, IND
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Abstract

Background

Acute myocardial infarction is associated with significant morbidity and mortality, particularly due to ventricular arrhythmias and sudden cardiac death. QT dispersion (QTd), reflecting heterogeneity of ventricular repolarization, may provide useful information regarding ventricular electrical instability in patients with acute myocardial infarction. This study assessed QT dispersion and evaluated its association with clinical characteristics, ventricular arrhythmias, and in-hospital outcome.

Methodology

This prospective observational study was conducted in a tertiary care hospital from June 2025 to June 2026. A total of 100 patients diagnosed with acute myocardial infarction were enrolled after obtaining written informed consent and Institutional Ethics Committee approval. A standard 12-lead electrocardiogram (ECG) was recorded at presentation, and QTd was calculated as the difference between the maximum and minimum QT intervals. A QTd value >42 ms was considered abnormal. Associations between QTd and clinical characteristics, ventricular arrhythmias, and in-hospital outcome were evaluated using chi-square and independent-samples t-tests, as appropriate.

Results

The study included 100 patients. The mean QTd was 80.71 ± 18.2 ms, with QTd >42 ms observed in 88 (88.0%) patients. Ventricular arrhythmias occurred in 30 (30.0%) patients, and mean QTd was significantly higher among patients with ventricular arrhythmias than among those without (94.9 ± 17.5 vs. 70.4 ± 9.82 ms; p < 0.001). Ventricular premature contractions were observed in 20 (20.0%) patients, while ventricular tachycardia and ventricular fibrillation occurred in 5 (5.0%) patients each. Patients who died during hospitalization had significantly higher mean QTd than survivors (121.0 ± 22.0 vs. 70.64 ± 9.82 ms; p < 0.001).

Conclusions

Increased QTd was frequently observed in patients with acute myocardial infarction and was significantly associated with ventricular arrhythmias and in-hospital mortality. These findings represent associations and should not be interpreted as evidence of independent prognostic prediction or causality. Larger multicenter studies with standardized ECG assessment and appropriate adjustment for potential confounders are warranted to determine the independent prognostic significance of QTd in acute myocardial infarction.

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Cite

BibTeXRIS
BibTeX
@article{ravichetti2026assessment,
  title = {{Assessment of QT Dispersion in Patients With Acute Myocardial Infarction}},
  author = {Akshara Ravichetti and Viswajeeth Kalivela and Madhu Yasarapu and Aishwarya Mantri and Shubham Jaju},
  journal = {Cureus},
  year = {2026},
  month = oct,
  doi = {10.7759/cureus.117373},
  url = {https://europepmc.org/article/PMC/PMC13725095},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Assessment of QT Dispersion in Patients With Acute Myocardial Infarction
AU  - Akshara Ravichetti
AU  - Viswajeeth Kalivela
AU  - Madhu Yasarapu
AU  - Aishwarya Mantri
AU  - Shubham Jaju
PY  - 2026
DA  - 2026/10/02
JO  - Cureus
DO  - 10.7759/cureus.117373
UR  - https://europepmc.org/article/PMC/PMC13725095
AB  - Background  Acute myocardial infarction is associated with significant morbidity and mortality, particularly due to ventricular arrhythmias and sudden cardiac death. QT dispersion (QTd), reflecting heterogeneity of ventricular repolarization, may provide useful information regarding ventricular electrical instability in patients with acute myocardial infarction. This study assessed QT dispersion and evaluated its association with clinical characteristics, ventricular arrhythmias, and in-hospital outcome.  Methodology  This prospective observational study was conducted in a tertiary care hospital from June 2025 to June 2026. A total of 100 patients diagnosed with acute myocardial infarction were enrolled after obtaining written informed consent and Institutional Ethics Committee approval. A standard 12-lead electrocardiogram (ECG) was recorded at presentation, and QTd was calculated as the difference between the maximum and minimum QT intervals. A QTd value >42 ms was considered abnormal. Associations between QTd and clinical characteristics, ventricular arrhythmias, and in-hospital outcome were evaluated using chi-square and independent-samples t-tests, as appropriate.  Results  The study included 100 patients. The mean QTd was 80.71 ± 18.2 ms, with QTd >42 ms observed in 88 (88.0%) patients. Ventricular arrhythmias occurred in 30 (30.0%) patients, and mean QTd was significantly higher among patients with ventricular arrhythmias than among those without (94.9 ± 17.5 vs. 70.4 ± 9.82 ms; p < 0.001). Ventricular premature contractions were observed in 20 (20.0%) patients, while ventricular tachycardia and ventricular fibrillation occurred in 5 (5.0%) patients each. Patients who died during hospitalization had significantly higher mean QTd than survivors (121.0 ± 22.0 vs. 70.64 ± 9.82 ms; p < 0.001).  Conclusions  Increased QTd was frequently observed in patients with acute myocardial infarction and was significantly associated with ventricular arrhythmias and in-hospital mortality. These findings represent associations and should not be interpreted as evidence of independent prognostic prediction or causality. Larger multicenter studies with standardized ECG assessment and appropriate adjustment for potential confounders are warranted to determine the independent prognostic significance of QTd in acute myocardial infarction.
SN  - 2168-8184
ER  -