Optical coherence tomography-defined radial artery calcification: frequency, phenotypes, and correlates in a retrospective transradial PCI cohort.
- 1Department of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
- 2Department of Emergency Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Abstract
Background and aims
The frequency, distribution, and optical coherence tomography (OCT) features of radial artery calcification (RAC) remain poorly defined. We assessed OCT-defined RAC and factors associated with patient-level RAC.Methods
This single-center retrospective observational study included 461 patients with analyzable radial artery OCT (RA-OCT) between January 2021 and August 2025. RAC was assessed at the patient, segment, and lesion levels. Clinical characteristics, radial artery plaque features, coronary OCT findings, and factors associated with patient-level RAC were evaluated.Results
Among 461 patients in the final analytic cohort, OCT-defined RAC was identified in 61 (13.2%). RAC involved the proximal, middle, and distal segments in 17/461 (3.7%), 25/461 (5.4%), and 52/461 (11.3%) patients, respectively. Among 214 calcified lesions, spotty calcification was the most common morphology (151/214, 70.6%). In exploratory patient-level analyses, all five radial artery plaque features were associated with RAC after multivariable adjustment, and all associations remained significant after Benjamini-Hochberg false discovery rate correction. In multivariable analysis, older age, diabetes mellitus, and coronary calcific nodule remained associated with RAC, whereas coronary calcium score was not statistically associated with RAC after adjustment.Conclusions
In this cohort, OCT-defined RAC was identified in 13.2% of patients, was more frequent in the distal segment, and showed heterogeneous lesion-level phenotypes. Older age, diabetes mellitus, and coronary calcific nodule were associated with RAC. Exploratory analyses also showed associations between RAC and multiple noncalcified radial artery plaque features.
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BibTeX
@article{he2026optical,
title = {{Optical coherence tomography-defined radial artery calcification: frequency, phenotypes, and correlates in a retrospective transradial PCI cohort.}},
author = {Saiying He and Jia Zhou and Hao Liu and Haotian Wang and Zixuan Li and Jincheng Guo},
journal = {Frontiers in medicine},
year = {2026},
month = oct,
doi = {10.3389/fmed.2026.1945441},
url = {https://europepmc.org/article/MED/43011197},
note = {CC BY},
}
RIS
TY - JOUR
TI - Optical coherence tomography-defined radial artery calcification: frequency, phenotypes, and correlates in a retrospective transradial PCI cohort.
AU - Saiying He
AU - Jia Zhou
AU - Hao Liu
AU - Haotian Wang
AU - Zixuan Li
AU - Jincheng Guo
PY - 2026
DA - 2026/10/27
JO - Frontiers in medicine
DO - 10.3389/fmed.2026.1945441
UR - https://europepmc.org/article/MED/43011197
AB - Background and aims The frequency, distribution, and optical coherence tomography (OCT) features of radial artery calcification (RAC) remain poorly defined. We assessed OCT-defined RAC and factors associated with patient-level RAC.Methods This single-center retrospective observational study included 461 patients with analyzable radial artery OCT (RA-OCT) between January 2021 and August 2025. RAC was assessed at the patient, segment, and lesion levels. Clinical characteristics, radial artery plaque features, coronary OCT findings, and factors associated with patient-level RAC were evaluated.Results Among 461 patients in the final analytic cohort, OCT-defined RAC was identified in 61 (13.2%). RAC involved the proximal, middle, and distal segments in 17/461 (3.7%), 25/461 (5.4%), and 52/461 (11.3%) patients, respectively. Among 214 calcified lesions, spotty calcification was the most common morphology (151/214, 70.6%). In exploratory patient-level analyses, all five radial artery plaque features were associated with RAC after multivariable adjustment, and all associations remained significant after Benjamini-Hochberg false discovery rate correction. In multivariable analysis, older age, diabetes mellitus, and coronary calcific nodule remained associated with RAC, whereas coronary calcium score was not statistically associated with RAC after adjustment.Conclusions In this cohort, OCT-defined RAC was identified in 13.2% of patients, was more frequent in the distal segment, and showed heterogeneous lesion-level phenotypes. Older age, diabetes mellitus, and coronary calcific nodule were associated with RAC. Exploratory analyses also showed associations between RAC and multiple noncalcified radial artery plaque features.
SN - 2296-858X
ER -