Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 32 min ago
Peer-reviewedCC BYParasite (Paris, France)

Experimental evidence for pigs as a potential long-term reservoir of Trypanosoma brucei gambiense.

  • Kouka Zoéwentallé Thibaut Ouédraogo1
  • Jacques Kabore1
  • Kadidiata Ilboudo1
  • Alain Boulangé2
  • Sophie Thevenon3
  • Robert Eustache Hounyeme4
  • Hassane Sakandé5
  • Mohamed Bamba5
  • Geoffrey Gimonneau3
  • Brice Rotureau6
  • Jean-Mathieu Bart7
  • Adrien Gaston Marie Belem8
5 more authors
  • Bruno Bucheton7
  • Marc Desquesnes9
  • David Berthier-Teyssedre3
  • Veerle Lejon7
  • Vincent Jamonneau10
10 affiliations
  1. 1Unité de Recherche sur les Maladies à Vecteurs et Biodiversité, Centre International de Recherche-Développement sur l'Élevage en Zone Subhumide, 01 BP 454, Bobo-Dioulasso 01, Burkina Faso - Unité de Formation et de Recherche Sciences et Techniques, Université Nazi Boni, 01 BP, 1091 Bobo-Dioulasso, Burkina-Faso.
  2. 2Unité de Recherche « Trypanosomoses », Institut Pierre Richet, 01 BP, 1500 Bouaké, Côte d'Ivoire - INTERTRYP, Univ Montpellier, Cirad, IRD, 34980 Montferrier-sur-Lez, France - CIRAD, UMR INTERTRYP, 34398 Montpellier, France.
  3. 3INTERTRYP, Univ Montpellier, Cirad, IRD, 34980 Montferrier-sur-Lez, France - CIRAD, UMR INTERTRYP, 34398 Montpellier, France.
  4. 4Unité de Recherche « Trypanosomoses », Institut Pierre Richet, 01 BP, 1500 Bouaké, Côte d'Ivoire.
  5. 5Unité de Recherche sur les Maladies à Vecteurs et Biodiversité, Centre International de Recherche-Développement sur l'Élevage en Zone Subhumide, 01 BP 454, Bobo-Dioulasso 01, Burkina Faso.
  6. 6Parasitology Unit, Institut Pasteur of Guinea, Route de Donka, BP 4416, Conakry, Guinea.
  7. 7INTERTRYP, Univ Montpellier, Cirad, IRD, 34980 Montferrier-sur-Lez, France.
  8. 8Institut du Développement Rural, Université Nazi Boni, 01 BP, 1091 Bobo-Dioulasso, Burkina-Faso.
  9. 9INTERTRYP, Univ Montpellier, Cirad, IRD, 34980 Montferrier-sur-Lez, France - CIRAD, UMR INTERTRYP, 34398 Montpellier, France - Université de Toulouse, ENVT, INRAE, IHAP, 23 Chemin des Capelles, 31300 Toulouse, France.
  10. 10Unité de Recherche « Trypanosomoses », Institut Pierre Richet, 01 BP, 1500 Bouaké, Côte d'Ivoire - INTERTRYP, Univ Montpellier, Cirad, IRD, 34980 Montferrier-sur-Lez, France.
Read full textPDFDOICite

Abstract

Pigs are suspected to act as a reservoir for Trypanosoma brucei gambiense and may therefore contribute to the re-emergence of human African trypanosomiasis (HAT), despite ongoing efforts to eliminate transmission. To clarify the role of this species in HAT epidemiology and to better understand the dynamics of T. b. gambiense infection in blood, we experimentally infected pigs with this parasite. In this study, we compared nine infected pigs with eight control pigs over a period of more than ten months using parasitological, molecular, and serological methods. The results showed that each diagnostic method has limitations, in terms of sensitivity to detect the presence of T. b. gambiense, and specificity to differentiate infection caused by T. b. gambiense from infection caused by T. b. brucei, responsible for animal African trypanosomosis. Nevertheless, the overall analysis showed that pigs can remain infected with T. b. gambiense for at least ten months. Hence, pigs should be considered a potential long-term reservoir of T. b. gambiense that could compromise the sustainability of the current elimination process. As a result, there is a need to pursue investigations on this topic, considering possible co-infections with T. b. brucei. In the meantime, adapted measures should be envisaged to limit contact between pigs and tsetse flies and/or to clear potential pig infections with T. b. gambiense by curative treatment.

Related

  1. Acalypha australis as a Potential Reservoir Host of Hop Stunt Viroid in Vineyards
    Gwang-Ho Yeom, Ju-Ho Bae, Sang-Yun Cho +1
    The plant pathology journalPeer-reviewedCC BY-NCFull textPlant biologyEurope PMC
  2. Skull Bone Marrow as a Cranial Neuroimmune Reservoir in Alzheimer’s Disease: Amyloid, Osteoimmune Remodeling, and Translational Imaging Evidence
    James Chmiel, Jerzy Leszek
    CellsPeer-reviewedCC BYFull textCell biologyEurope PMC
  3. Microfluidic Capture-Enrichment of individualized microbes from urban wastewater reveals a hidden reservoir of potential pre-emergent pathogens
    S. Zhou, S. Seo, k. Rhatigan +9
    bioRxivPreprintCC BYFull textMicrobiologybioRxiv
  4. Agricultural soils as a potential reservoir of mycotoxigenic Fusarium spp. in northwest Spain.
    Rocio Montes-Ruiz, Mario Masiello, Lucia Gambacorta +6
    Frontiers in fungal biologyPeer-reviewedCC BYFull textPlant biologyEurope PMC
  5. Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir
    Mauro A. Garcia, Anna Farrell-Sherman, Beril Aydin +22
    Proceedings of the National Academy of SciencesPeer-reviewedCC BY-NC-ND6 citedMicrobiologyOpenAlex

Cite

BibTeXRIS
BibTeX
@article{ouedraogo2026experimental,
  title = {{Experimental evidence for pigs as a potential long-term reservoir of Trypanosoma brucei gambiense.}},
  author = {Kouka Zoéwentallé Thibaut Ouédraogo and Jacques Kabore and Kadidiata Ilboudo and Alain Boulangé and Sophie Thevenon and Robert Eustache Hounyeme and Hassane Sakandé and Mohamed Bamba and Geoffrey Gimonneau and Brice Rotureau and Jean-Mathieu Bart and Adrien Gaston Marie Belem and Bruno Bucheton and Marc Desquesnes and David Berthier-Teyssedre and Veerle Lejon and Vincent Jamonneau},
  journal = {Parasite (Paris, France)},
  year = {2026},
  month = oct,
  doi = {10.1051/parasite/2026061},
  url = {https://europepmc.org/article/MED/42949413},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Experimental evidence for pigs as a potential long-term reservoir of Trypanosoma brucei gambiense.
AU  - Kouka Zoéwentallé Thibaut Ouédraogo
AU  - Jacques Kabore
AU  - Kadidiata Ilboudo
AU  - Alain Boulangé
AU  - Sophie Thevenon
AU  - Robert Eustache Hounyeme
AU  - Hassane Sakandé
AU  - Mohamed Bamba
AU  - Geoffrey Gimonneau
AU  - Brice Rotureau
AU  - Jean-Mathieu Bart
AU  - Adrien Gaston Marie Belem
AU  - Bruno Bucheton
AU  - Marc Desquesnes
AU  - David Berthier-Teyssedre
AU  - Veerle Lejon
AU  - Vincent Jamonneau
PY  - 2026
DA  - 2026/10/28
JO  - Parasite (Paris, France)
DO  - 10.1051/parasite/2026061
UR  - https://europepmc.org/article/MED/42949413
AB  - Pigs are suspected to act as a reservoir for Trypanosoma brucei gambiense and may therefore contribute to the re-emergence of human African trypanosomiasis (HAT), despite ongoing efforts to eliminate transmission. To clarify the role of this species in HAT epidemiology and to better understand the dynamics of T. b. gambiense infection in blood, we experimentally infected pigs with this parasite. In this study, we compared nine infected pigs with eight control pigs over a period of more than ten months using parasitological, molecular, and serological methods. The results showed that each diagnostic method has limitations, in terms of sensitivity to detect the presence of T. b. gambiense, and specificity to differentiate infection caused by T. b. gambiense from infection caused by T. b. brucei, responsible for animal African trypanosomosis. Nevertheless, the overall analysis showed that pigs can remain infected with T. b. gambiense for at least ten months. Hence, pigs should be considered a potential long-term reservoir of T. b. gambiense that could compromise the sustainability of the current elimination process. As a result, there is a need to pursue investigations on this topic, considering possible co-infections with T. b. brucei. In the meantime, adapted measures should be envisaged to limit contact between pigs and tsetse flies and/or to clear potential pig infections with T. b. gambiense by curative treatment.
SN  - 1252-607X
SN  - 1776-1042
ER  -