Single-Nucleotide Polymorphisms in Calcium and Vitamin D Maintenance Genes Association With Tooth Size.
4 affiliations
- 1School of Dentistry, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil.
- 2Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
- 3School of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.
- 4Department of Orthodontics, University Hospital Bonn, Medical Faculty, Bonn, Nordrhein-Westfalen, Germany.
Abstract
This study investigated the association between Single Nucleotide Polymorphisms (SNPs) in calcium and vitamin D maintenance genes and mesiodistal tooth size (MTS) of permanent teeth. A total of 108 patients undergoing orthodontic treatment were recruited. Pretreatment orthodontic diagnostic casts were used to obtain the MTS. One single calibrated evaluator assessed the maximum crown dimensions in the mesiodistal direction of mandibular and maxillary permanent teeth with a digital caliper. Salivary genomic DNA was isolated from buccal cells, and six SNPs of the VDR, CYP24A1, CYP27B1, and PTH genes were selected. Real-Time PCR was performed for the genotyping analysis. For statistics analysis, uni- and multivariate tests accounting for multiple observations per-subject and adjusted by gender were performed (α = 5%). In multivariate analysis, the rs694 and rs6256 (PTH) SNPs were associated (p < 0.05) with smaller MTS of the maxillary first molar. The rs7975232 (VDR) and rs307247 (PTH) were associated with a smaller mesiodistal size of the mandibular first molar. The rs7975232 (VDR) was also associated with a smaller mesiodistal size of the maxillary central incisor and a greater mesiodistal size of the maxillary first premolar. The rs4646536 (CYP27B1) was also associated with greater mesiodistal size of the first premolar. SNPs in the PTH and vitamin D-related genes (VDR and CYP27B1) might be related to MTS variations of permanent teeth.
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BibTeX
@article{rodrigues2026singlenucleotide,
title = {{Single-Nucleotide Polymorphisms in Calcium and Vitamin D Maintenance Genes Association With Tooth Size.}},
author = {Lucas Cabral Rodrigues and Mirian Aiko Nakane Matsumoto and Maria Bernadete Sasso Stuani and Guido Artemio Marañón-Vásquez and Fábio Lourenço Romano and Daniela Silva Barroso de Oliveira and Juliane Cora da Silva and Flares Baratto-Filho and Christian Kirschneck and Erika Calvano Küchler and Caio Luiz Bitencourt Reis},
journal = {Clinical and experimental dental research},
year = {2026},
month = oct,
doi = {10.1002/cre2.70472},
url = {https://europepmc.org/article/MED/42956174},
note = {CC BY},
}
RIS
TY - JOUR
TI - Single-Nucleotide Polymorphisms in Calcium and Vitamin D Maintenance Genes Association With Tooth Size.
AU - Lucas Cabral Rodrigues
AU - Mirian Aiko Nakane Matsumoto
AU - Maria Bernadete Sasso Stuani
AU - Guido Artemio Marañón-Vásquez
AU - Fábio Lourenço Romano
AU - Daniela Silva Barroso de Oliveira
AU - Juliane Cora da Silva
AU - Flares Baratto-Filho
AU - Christian Kirschneck
AU - Erika Calvano Küchler
AU - Caio Luiz Bitencourt Reis
PY - 2026
DA - 2026/10/01
JO - Clinical and experimental dental research
DO - 10.1002/cre2.70472
UR - https://europepmc.org/article/MED/42956174
AB - This study investigated the association between Single Nucleotide Polymorphisms (SNPs) in calcium and vitamin D maintenance genes and mesiodistal tooth size (MTS) of permanent teeth. A total of 108 patients undergoing orthodontic treatment were recruited. Pretreatment orthodontic diagnostic casts were used to obtain the MTS. One single calibrated evaluator assessed the maximum crown dimensions in the mesiodistal direction of mandibular and maxillary permanent teeth with a digital caliper. Salivary genomic DNA was isolated from buccal cells, and six SNPs of the VDR, CYP24A1, CYP27B1, and PTH genes were selected. Real-Time PCR was performed for the genotyping analysis. For statistics analysis, uni- and multivariate tests accounting for multiple observations per-subject and adjusted by gender were performed (α = 5%). In multivariate analysis, the rs694 and rs6256 (PTH) SNPs were associated (p < 0.05) with smaller MTS of the maxillary first molar. The rs7975232 (VDR) and rs307247 (PTH) were associated with a smaller mesiodistal size of the mandibular first molar. The rs7975232 (VDR) was also associated with a smaller mesiodistal size of the maxillary central incisor and a greater mesiodistal size of the maxillary first premolar. The rs4646536 (CYP27B1) was also associated with greater mesiodistal size of the first premolar. SNPs in the PTH and vitamin D-related genes (VDR and CYP27B1) might be related to MTS variations of permanent teeth.
SN - 2057-4347
ER -