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Peer-reviewedCC BYNature Neuroscience

Comprehensive profiling of brain dynamics during anesthesia across phylogeny

  • Andrea I. Luppi1,2,3
  • Lynn Uhrig4,5
  • Jordy Tasserie6,4
  • Golia Shafiei7,8
  • Antoine Légaré9
  • Kanako Muta10,11
  • Junichi Hata10,11
  • Hideyuki Okano12,11
  • Daniel Golkowski13,14
  • Andreas Ranft15
  • Rüdiger Ilg16,13
  • Denis Jordan17,18
16 more authors
  • Silvia Gini19,20
  • Zhen-Qi Liu8
  • Yohan Yee21,8
  • Pablo Castro4,22
  • Camilo Miguel Signorelli23,4
  • Rodrigo Cofré24,22
  • Alain Destexhe A22
  • David Krishna Menon25
  • Emmanuel Andreas Stamatakis26,25
  • Patrick Desrosiers27
  • Paul De Koninck27
  • Christopher W. Connor28,29
  • Alessandro Gozzi19
  • Ben Fulcher30
  • Béchir Jarraya31,32
  • Bratislav Mišić33
33 affiliations
  1. 1Department of Psychiatry and Centre for Eudaimonia and Human Flourishing, University of Oxford, Oxford, UK. [email protected]
  2. 2Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada. [email protected]
  3. 3St John's College, University of Cambridge, Cambridge, UK. [email protected]
  4. 4Cognitive Neuroimaging Unit, CEA, INSERM, Université Paris-Saclay, NeuroSpin Center, Gif-sur-Yvette, France
  5. 5Department of Anesthesiology and Critical Care, Necker Hospital, Université de Paris Cité, Paris, France
  6. 6Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
  7. 7Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  8. 8Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada
  9. 9Centre de recherche CERVO, Quebec City, Quebec, Canada
  10. 10Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan
  11. 11Laboratory for Marmoset Models of Brain Diseases, RIKEN Center for Brain Science, Wako, Japan
  12. 12Keio University Regenerative Medicine Research Center, Kawasaki, Japan
  13. 13Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
  14. 14Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
  15. 15Department of Anesthesiology and Intensive Care, Technical University of Munich, Munich, Germany
  16. 16Department of Neurology, Asklepios Clinic, Bad Tolz, Germany
  17. 17Department of Anaesthesiology and Intensive Care Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
  18. 18University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland
  19. 19Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy
  20. 20Centre for Mind/Brain Sciences, University of Trento, Trento, Italy
  21. 21Department of Radiology, University of Calgary, Calgary, Alberta, Canada
  22. 22Paris-Saclay University, CNRS, Paris-Saclay Institute for Neuroscience (NeuroPSI), Saclay, France
  23. 23Center for Philosophy of Artificial Intelligence, University of Copenhagen, Copenhagen, Denmark
  24. 24Inria Centre, Université Côte d'Azur Nice, Valbonne, France
  25. 25Division of Anaesthesia, University of Cambridge, Cambridge, UK
  26. 26Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
  27. 27Université Laval, Quebec City, Quebec, Canada
  28. 28Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA
  29. 29Department of Biomedical Engineering, Physiology and Biophysics, Boston University, Boston, MA, USA
  30. 30School of Physics, The University of Sydney, Sydney, New South Wales, Australia
  31. 31Cognitive Neuroimaging Unit, CEA, INSERM, Université Paris-Saclay, NeuroSpin Center, Gif-sur-Yvette, France. [email protected]
  32. 32Department of Neurology, Foch Hospital, Suresnes, France. [email protected]
  33. 33Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada. [email protected]
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Abstract

The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, zebrafish and nematode. Applying massive feature extraction, we characterize local neural dynamics across >6,000 time-series features. This reveals a conserved dynamical profile of anesthesia across species, characterized by shorter intrinsic timescales of neural activity and dampened inter-regional synchrony. Deep-brain stimulation of the macaque centromedian thalamus reverses this profile and restores behavioral responsiveness. This conserved dynamical phenotype covaries with conserved transcriptional profiles of excitatory and inhibitory neurotransmission. Biophysical modeling provides a potential mechanistic link between the macroscale dynamical phenotype of anesthesia and microscale effects of key molecular targets on the timescales of synaptic excitation and inhibition. These analyses reveal a shared neural endpoint of anesthesia: across species and scales, anesthetics induce spatiotemporal isolation of local neural activity.

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Cite

BibTeXRIS
BibTeX
@article{luppi2026comprehensive,
  title = {{Comprehensive profiling of brain dynamics during anesthesia across phylogeny}},
  author = {Andrea I. Luppi and Lynn Uhrig and Jordy Tasserie and Golia Shafiei and Antoine Légaré and Kanako Muta and Junichi Hata and Hideyuki Okano and Daniel Golkowski and Andreas Ranft and Rüdiger Ilg and Denis Jordan and Silvia Gini and Zhen-Qi Liu and Yohan Yee and Pablo Castro and Camilo Miguel Signorelli and Rodrigo Cofré and Alain Destexhe A and David Krishna Menon and Emmanuel Andreas Stamatakis and Patrick Desrosiers and Paul De Koninck and Christopher W. Connor and Alessandro Gozzi and Ben Fulcher and Béchir Jarraya and Bratislav Mišić},
  journal = {Nature Neuroscience},
  year = {2026},
  month = sep,
  doi = {10.1038/s41593-026-02460-4},
  url = {https://inria.hal.science/hal-05769145v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Comprehensive profiling of brain dynamics during anesthesia across phylogeny
AU  - Andrea I. Luppi
AU  - Lynn Uhrig
AU  - Jordy Tasserie
AU  - Golia Shafiei
AU  - Antoine Légaré
AU  - Kanako Muta
AU  - Junichi Hata
AU  - Hideyuki Okano
AU  - Daniel Golkowski
AU  - Andreas Ranft
AU  - Rüdiger Ilg
AU  - Denis Jordan
AU  - Silvia Gini
AU  - Zhen-Qi Liu
AU  - Yohan Yee
AU  - Pablo Castro
AU  - Camilo Miguel Signorelli
AU  - Rodrigo Cofré
AU  - Alain Destexhe A
AU  - David Krishna Menon
AU  - Emmanuel Andreas Stamatakis
AU  - Patrick Desrosiers
AU  - Paul De Koninck
AU  - Christopher W. Connor
AU  - Alessandro Gozzi
AU  - Ben Fulcher
AU  - Béchir Jarraya
AU  - Bratislav Mišić
PY  - 2026
DA  - 2026/09/29
JO  - Nature Neuroscience
DO  - 10.1038/s41593-026-02460-4
UR  - https://inria.hal.science/hal-05769145v1
AB  - The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, zebrafish and nematode. Applying massive feature extraction, we characterize local neural dynamics across >6,000 time-series features. This reveals a conserved dynamical profile of anesthesia across species, characterized by shorter intrinsic timescales of neural activity and dampened inter-regional synchrony. Deep-brain stimulation of the macaque centromedian thalamus reverses this profile and restores behavioral responsiveness. This conserved dynamical phenotype covaries with conserved transcriptional profiles of excitatory and inhibitory neurotransmission. Biophysical modeling provides a potential mechanistic link between the macroscale dynamical phenotype of anesthesia and microscale effects of key molecular targets on the timescales of synaptic excitation and inhibition. These analyses reveal a shared neural endpoint of anesthesia: across species and scales, anesthetics induce spatiotemporal isolation of local neural activity.
SN  - 1097-6256
SN  - 1546-1726
ER  -