Primary angiosarcoma of the nasal septum: a rare case report and literature review
- 1Department of Otorhinolaryngology-Head and Neck Surgery, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Abstract
Objectives: Angiosarcoma is a rare malignant vascular tumour. Its occurrence in the nasal cavity is uncommon, and septal cases are particularly rare. Because symptoms are often non-specific, nasal septal angiosarcoma may initially mimic benign vascular lesion and delay diagnosis.
Methods: We report a 46-year-old woman with recurrent epistaxis and nasal obstruction. Nasal endoscopy and excisional biopsy were performed, with histopathology and immunohistochemistry.
Results: Endoscopy revealed a 1.0 × 0.5 cm mass on the anterior septum. The lesion appeared completely excised on gross inspection; however, histopathology demonstrated infiltrative margins with residual tumour at the resection edges. Microscopy showed irregular vascular channels, pleomorphic endothelial cells, high mitotic activity and focal necrosis. Immunohistochemistry confirmed endothelial differentiation. No cartilage invasion was identified on histology.
Conclusion: This case highlights the diagnostic challenge of nasal septal angiosarcoma and the emphasises the importance of early biopsy, histopathological confirmation and multidisciplinary management.
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BibTeX
@article{kang2026primary,
title = {{Primary angiosarcoma of the nasal septum: a rare case report and literature review}},
author = {Yun Jin Kang and Min Su Kim and Youn Sun Park and Jin-Hee Cho},
journal = {The Journal of Laryngology and Otology},
year = {2026},
month = nov,
doi = {10.1017/s0022215126104678},
url = {https://doi.org/10.1017/s0022215126104678},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Primary angiosarcoma of the nasal septum: a rare case report and literature review
AU - Yun Jin Kang
AU - Min Su Kim
AU - Youn Sun Park
AU - Jin-Hee Cho
PY - 2026
DA - 2026/11/06
JO - The Journal of Laryngology and Otology
DO - 10.1017/s0022215126104678
UR - https://doi.org/10.1017/s0022215126104678
AB - Objectives: Angiosarcoma is a rare malignant vascular tumour. Its occurrence in the nasal cavity is uncommon, and septal cases are particularly rare. Because symptoms are often non-specific, nasal septal angiosarcoma may initially mimic benign vascular lesion and delay diagnosis. Methods: We report a 46-year-old woman with recurrent epistaxis and nasal obstruction. Nasal endoscopy and excisional biopsy were performed, with histopathology and immunohistochemistry. Results: Endoscopy revealed a 1.0 × 0.5 cm mass on the anterior septum. The lesion appeared completely excised on gross inspection; however, histopathology demonstrated infiltrative margins with residual tumour at the resection edges. Microscopy showed irregular vascular channels, pleomorphic endothelial cells, high mitotic activity and focal necrosis. Immunohistochemistry confirmed endothelial differentiation. No cartilage invasion was identified on histology. Conclusion: This case highlights the diagnostic challenge of nasal septal angiosarcoma and the emphasises the importance of early biopsy, histopathological confirmation and multidisciplinary management.
SN - 0022-2151
SN - 1748-5460
ER -